ACSM2B

ACSM2B
Identifiers
Aliases	ACSM2B, ACSM2, HXMA, HYST1046, acyl-CoA synthetase medium-chain family member 2B, acyl-CoA synthetase medium chain family member 2B
External IDs	OMIM: 614359; MGI: 2385289; HomoloGene: 89289; GeneCards: ACSM2B; OMA:ACSM2B - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 16 (human)
End	20,576,427 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	119,199,913 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; renal cortex; ; human kidney; ; testicle; ; gonad; ; epithelium of colon; ; sural nerve; ; left uterine tube; ; renal medulla; ; muscle of thigh;
	Top expressed in
	right kidney; ; proximal tubule; ; human kidney; ; primary visual cortex; ; morula; ; muscle of thigh; ; hair follicle; ; zygote; ; superior frontal gyrus; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ligase activity; catalytic activity; ATP binding; metal ion binding; butyrate-CoA ligase activity; CoA-ligase activity; fatty-acyl-CoA synthase activity; fatty acid ligase activity; molecular function;
Cellular component	mitochondrion; mitochondrial matrix;
Biological process	xenobiotic metabolic process; metabolism; fatty acid metabolic process; lipid metabolism; fatty acid biosynthetic process; acyl-CoA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	348158
	233799
	ENSG00000066813
	ENSMUSG00000030945
	Q68CK6
	Q8K0L3
	NM_001105069; NM_182617
	NM_001177977; NM_001177978; NM_146197
	NP_001098539; NP_872423
	NP_001171448; NP_001171449; NP_666309
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA synthetase medium-chain family member 2B (ACSM2B) is a mitochondrial enzyme that in humans is encoded by the ACSM2B gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000066813 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030945 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vessey DA, Lau E, Kelley M, Warren RS (Mar 2003). "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria". J Biochem Mol Toxicol. 17 (1): 1–6. doi:10.1002/jbt.10056. PMID 12616642. S2CID 13396633.
↑ "Entrez Gene: ACSM2 acyl-CoA synthetase medium-chain family member 2".

External links

Human ACSM2B genome location and ACSM2B gene details page in the UCSC Genome Browser.

Lindner I, Rubin D, Helwig U, et al. (2006). "The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population". Mol Nutr Food Res. 50 (3): 270–4. doi:10.1002/mnfr.200500241. PMID 16521160.
Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
Vessey DA, Kelley M, Warren RS (2004). "Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver". J. Biochem. Mol. Toxicol. 18 (2): 100–6. doi:10.1002/jbt.20009. PMID 15122652. S2CID 8154380.
Vessey DA, Kelley M (2001). "Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase". Biochem. J. 357 (Pt 1): 283–8. doi:10.1042/0264-6021:3570283. PMC 1221953. PMID 11415461.
Vessey DA, Kelley M, Warren RS (1999). "Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids". Biochim. Biophys. Acta. 1428 (2–3): 455–62. doi:10.1016/s0304-4165(99)00088-4. PMID 10434065.
Vessey DA, Hu J (1997). "Isolation from bovine liver mitochondria and characterization of three distinct carboxylic acid: CoA ligases with activity toward xenobiotics". J. Biochem. Toxicol. 10 (6): 329–37. doi:10.1002/jbt.2570100608. PMID 8934636.
Vessey DA, Hu J, Kelley M (1997). "Interaction of salicylate and ibuprofen with the carboxylic acid: CoA ligases from bovine liver mitochondria". J. Biochem. Toxicol. 11 (2): 73–8. doi:10.1002/(SICI)1522-7146(1996)11:2<73::AID-JBT4>3.0.CO;2-R. PMID 8884467.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000066813 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030945 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12616642-5] Vessey DA, Lau E, Kelley M, Warren RS (Mar 2003). "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria". J Biochem Mol Toxicol. 17 (1): 1–6. doi:10.1002/jbt.10056. PMID 12616642. S2CID 13396633.

[entrez-6] "Entrez Gene: ACSM2 acyl-CoA synthetase medium-chain family member 2".

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ACSM2B

References

External links

Further reading