FGF22

FGF22
Identifiers
Aliases	FGF22, fibroblast growth factor 22
External IDs	OMIM: 605831; MGI: 1914362; GeneCards: FGF22
Gene location (Human)
Chr.	Chromosome 19 (human)
End	644,373 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,594,430 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; right frontal lobe; ; anterior cingulate cortex; ; Brodmann area 9; ; prefrontal cortex; ; left ovary; ; putamen; ; nucleus accumbens; ; amygdala;
	Top expressed in
	lip; ; skin of abdomen; ; skin of back; ; esophagus; ; embryo; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; hair follicle; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	fibroblast growth factor receptor binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein tyrosine kinase activity; 1-phosphatidylinositol-3-kinase activity;
Cellular component	extracellular region; extracellular space; nucleolus; Golgi apparatus; cell surface;
Biological process	cell differentiation; MAPK cascade; fibroblast growth factor receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	27006
	67112
	ENSG00000070388
	ENSMUSG00000020327
	Q9HCT0
	Q9ESS2
	NM_020637; NM_001300812
	NM_023304; NM_001368662
	NP_001287741; NP_065688
	NP_075793; NP_001355591
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 22 is a protein which in humans is encoded by the FGF22 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070388 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020327 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Umemori H, Linhoff MW, Ornitz DM, Sanes JR (July 2004). "FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain". Cell. 118 (2): 257–70. doi:10.1016/j.cell.2004.06.025. PMID 15260994. S2CID 18836066.
↑ Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM (June 2006). "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". The Journal of Biological Chemistry. 281 (23): 15694–700. doi:10.1074/jbc.M601252200. PMC 2080618. PMID 16597617.
↑ "Entrez Gene: Fibroblast growth factor 22".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070388 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020327 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15260994-5] Umemori H, Linhoff MW, Ornitz DM, Sanes JR (July 2004). "FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain". Cell. 118 (2): 257–70. doi:10.1016/j.cell.2004.06.025. PMID 15260994. S2CID 18836066.

[pmid16597617-6] Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM (June 2006). "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". The Journal of Biological Chemistry. 281 (23): 15694–700. doi:10.1074/jbc.M601252200. PMC 2080618. PMID 16597617.

[entrez-7] "Entrez Gene: Fibroblast growth factor 22".

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Function

References