FGF16

FGF16
Identifiers
Aliases	FGF16, FGF-16, MF4, fibroblast growth factor 16
External IDs	OMIM: 300827; MGI: 1931627; GeneCards: FGF16
Gene location (Human)
Chr.	X chromosome (human)
End	77,457,278 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	104,818,545 bp
RNA expression pattern
	Top expressed in
	gonad; ; thigh; ; muscle of thigh; ; subcutaneous adipose tissue; ; right coronary artery; ; ventricular zone; ; smooth muscle tissue; ; apex of heart; ; prefrontal cortex; ; thoracic aorta;
	Top expressed in
	interventricular septum; ; nasal placode; ; otic pit; ; semicircular canal; ; right ventricle; ; posterior semicircular canal; ; embryo; ; myocardium of ventricle; ; anterior semicircular canal; ; cardiac muscles;
	More reference expression data
	n/a
Gene ontology
Molecular function	fibroblast growth factor receptor binding; growth factor activity; 1-phosphatidylinositol-3-kinase activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	regulation of sprouting angiogenesis; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; cell-cell signaling; MAPK cascade; fibroblast growth factor receptor signaling pathway; positive regulation of brown fat cell proliferation; regulation of endothelial cell proliferation; animal organ morphogenesis; regulation of MAP kinase activity; signal transduction; response to temperature stimulus; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8823
	80903
	ENSG00000196468
	ENSMUSG00000031230
	O43320
	Q9ESL8
	NM_003868
	NM_030614
	NP_003859
	NP_085117
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 16 is a protein which in humans is encoded by the FGF16 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The rat homolog is predominantly expressed in embryonic brown adipose tissue and has significant mitogenic activity, which suggests a role in proliferation of embryonic brown adipose tissue.^[7]

Mutations in this gene have been found associated to cases of X-linked recessive metacarpal 4/5 fusion.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196468 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031230 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Miyake A, Konishi M, Martin FH, Hernday NA, Ozaki K, Yamamoto S, Mikami T, Arakawa T, Itoh N (February 1998). "Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family". Biochemical and Biophysical Research Communications. 243 (1): 148–52. Bibcode:1998BBRC..243..148M. doi:10.1006/bbrc.1998.8073. PMID 9473496.
↑ Kim HS (2001). "The human FGF gene family: chromosome location and phylogenetic analysis". Cytogenetics and Cell Genetics. 93 (1–2): 131–2. doi:10.1159/000056965. PMID 11474196. S2CID 20876318.
↑ "Entrez Gene: Fibroblast growth factor 16".
↑ Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, Doelken SC, Glazar R, Socha M, Mundlos S (September 2013). "Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion". Journal of Medical Genetics. 50 (9): 579–84. doi:10.1136/jmedgenet-2013-101659. PMID 23709756. S2CID 9501794.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196468 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031230 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9473496-5] Miyake A, Konishi M, Martin FH, Hernday NA, Ozaki K, Yamamoto S, Mikami T, Arakawa T, Itoh N (February 1998). "Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family". Biochemical and Biophysical Research Communications. 243 (1): 148–52. Bibcode:1998BBRC..243..148M. doi:10.1006/bbrc.1998.8073. PMID 9473496.

[pmid11474196-6] Kim HS (2001). "The human FGF gene family: chromosome location and phylogenetic analysis". Cytogenetics and Cell Genetics. 93 (1–2): 131–2. doi:10.1159/000056965. PMID 11474196. S2CID 20876318.

[entrez-7] "Entrez Gene: Fibroblast growth factor 16".

[pmid23709756-8] Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, Doelken SC, Glazar R, Socha M, Mundlos S (September 2013). "Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion". Journal of Medical Genetics. 50 (9): 579–84. doi:10.1136/jmedgenet-2013-101659. PMID 23709756. S2CID 9501794.

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Function

References