// Workers AI · dad joke modeWhat did STX1B say to its date? You're a complex binding partner.

STX1B
Identifiers
Aliases	STX1B, STX1B1, STX1B2, GEFSP9, syntaxin 1B
External IDs	OMIM: 601485; MGI: 1930705; HomoloGene: 69375; GeneCards: STX1B; OMA:STX1B - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 30,989,256 bp End 31,010,638 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 127,403,072 bp End 127,423,721 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 prefrontal cortex cingulate gyrus anterior cingulate cortex postcentral gyrus superior frontal gyrus nucleus accumbens hypothalamus Top expressed in superior frontal gyrus cerebellar cortex dentate gyrus of hippocampal formation granule cell pontine nuclei dorsal tegmental nucleus dorsomedial hypothalamic nucleus cerebellar vermis medial vestibular nucleus lobe of cerebellum subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein kinase binding signaling receptor binding SNARE binding protein domain specific binding Cellular component integral component of membrane cytosol membrane synaptic vesicle plasma membrane spindle microtubule organizing center SNARE complex cytoskeleton nuclear lamina nucleus nucleoplasm centrosome cytoplasm presynaptic membrane presynapse presynaptic active zone membrane axon neuromuscular junction endomembrane system Biological process synaptic vesicle docking spontaneous neurotransmitter secretion positive regulation of neurotransmitter secretion regulation of exocytosis vesicle docking positive regulation of excitatory postsynaptic potential regulation of gene expression protein transport intracellular protein transport neurotransmitter transport vesicle-mediated transport regulation of synaptic vesicle priming negative regulation of neuron projection development regulation of synaptic activity vesicle docking involved in exocytosis calcium ion-regulated exocytosis of neurotransmitter protein localization to membrane negative regulation of synaptic vesicle recycling positive regulation of spontaneous neurotransmitter secretion negative regulation of macropinocytosis synaptic vesicle fusion to presynaptic active zone membrane exocytic insertion of neurotransmitter receptor to postsynaptic membrane synaptic vesicle exocytosis exocytosis vesicle fusion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 112755 56216 Ensembl ENSG00000099365 ENSMUSG00000030806 UniProt P61266 P61264 RefSeq (mRNA) NM_052874 NM_024414 RefSeq (protein) NP_443106 NP_077725 Location (UCSC) Chr 16: 30.99 – 31.01 Mb Chr 7: 127.4 – 127.42 Mb PubMed search
Wikidata
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Syntaxin-1B is a protein that in humans is encoded by the STX1B gene.

Interactions

STX1B has been shown to interact with UNC13B.

Further reading

• Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
• Pérez-Brangulí F, Muhaisen A, Blasi J (June 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Molecular and Cellular Neurosciences. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152. S2CID 23927545.
• Nagamatsu S, Nakamichi Y, Watanabe T, Matsushima S, Yamaguchi S, Ni J, Itagaki E, Ishida H (January 2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules". Journal of Cell Science. 114 (Pt 1): 219–227. doi:10.1242/jcs.114.1.219. PMID 11112705.
• Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
• Smirnova T, Miniou P, Viegas-Pequignot E, Mallet J (September 1996). "Assignment of the human syntaxin 1B gene (STX) to chromosome 16p11.2 by fluorescence in situ hybridization". Genomics. 36 (3): 551–3. doi:10.1006/geno.1996.0506. PMID 8884284.
• Smirnova T, Stinnakre J, Mallet J (October 1993). "Characterization of a presynaptic glutamate receptor". Science. 262 (5132): 430–3. Bibcode:1993Sci...262..430S. doi:10.1126/science.8105537. PMID 8105537.