AP1AR

AP1AR
Identifiers
Aliases	AP1AR, 2C18, C4orf16, GBAR, gamma-BAR, PRO0971, adaptor related protein complex 1 associated regulatory protein
External IDs	OMIM: 610851; MGI: 2384822; GeneCards: AP1AR
Gene location (Human)
Chr.	Chromosome 4 (human)
End	112,273,110 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	127,631,172 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; jejunal mucosa; ; rectum; ; monocyte; ; testicle; ; ventricular zone; ; mucosa of sigmoid colon; ; stromal cell of endometrium; ; islet of Langerhans;
	Top expressed in
	trigeminal ganglion; ; epithelium of small intestine; ; conjunctival fornix; ; vestibular membrane of cochlear duct; ; dorsal striatum; ; Ileal epithelium; ; primitive streak; ; corneal stroma; ; entorhinal cortex; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinesin binding; AP-1 adaptor complex binding;
Cellular component	late endosome; Golgi apparatus; early endosome; transport vesicle; cytosol; endosome;
Biological process	protein transport; negative regulation of cell motility; negative regulation of substrate adhesion-dependent cell spreading; regulation of Arp2/3 complex-mediated actin nucleation; negative regulation of receptor recycling; vesicle targeting, trans-Golgi to endosome;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55435
	211556
	ENSG00000138660
	ENSMUSG00000074238
	Q63HQ0
	n/a
	NM_001128426; NM_018569
	NM_145964; NM_001346718
	NP_001121898; NP_061039
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

AP-1 complex-associated regulatory protein (Gamma1-adaptin brefeldin A resistance protein) is a protein that in humans is encoded by the AP1AR gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138660 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074238 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (Apr 2005). "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO J. 24 (6): 1122–33. doi:10.1038/sj.emboj.7600600. PMC 556403. PMID 15775984.
↑ "Entrez Gene: C4orf16 chromosome 4 open reading frame 16".

External links

Human AP1AR genome location and AP1AR gene details page in the UCSC Genome Browser.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138660 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074238 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15775984-5] Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (Apr 2005). "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO J. 24 (6): 1122–33. doi:10.1038/sj.emboj.7600600. PMC 556403. PMID 15775984.

[entrez-6] "Entrez Gene: C4orf16 chromosome 4 open reading frame 16".

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AP1AR

References

External links

Further reading