RCOR2
| RCOR2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | RCOR2, REST corepressor 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 616019; MGI: 1859854; HomoloGene: 14280; GeneCards: RCOR2; OMA:RCOR2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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REST corepressor 2 also known as CoREST2 is a protein that in humans is encoded by the RCOR2 gene.[5]
CoREST2 acts as a transcriptional corepressor protein that regulates gene expression and is required for stem cell pluripotency[6] and neurogenesis.[7]
As an oncogene in neuroblastoma
[edit]A non-canonical role of RCoR2 (REST corepressor 2) has been described in the adrenergic lineage of neuroblastoma, expanding its established function as a transcriptional corepressor. In this context, RCOR2, driven by a super-enhancer and functionally distinct from its paralogs, can act as a positive regulator that facilitates genomics contacts between core regulatory circuitry (CRC)-bound enhancers and their target core promoters, thereby sustaining gene-expression programs that preserve adrenergic cell identity and promote tumor cell proliferation. This activating behavior challenges the traditional view of RCOR2 as exclusively part of repressive complexes and highlights the functional plasticity of HDAC containing chromatin regulators in pediatric cancers, identifying RCOR2 as a potential therapeutic vulnerability in adrenergic neuroblastoma.[8][9]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000167771 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024968 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: RCOR2 – REST corepressor 2".
- ↑ Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, et al. (May 2011). "RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency". Stem Cells. 29 (5). Dayton, Ohio: 791–801. doi:10.1002/stem.634. PMID 21433225.
- ↑ Lam XJ, Maniam S, Cheah PS, Ling KH (October 2023). "REST in the Road Map of Brain Development". Cellular and Molecular Neurobiology. 43 (7): 3417–3433. doi:10.1007/s10571-023-01394-w. PMC 11410019. PMID 37517069.
- ↑ Aloisi S, Santulli M, Russo M, Zadran SK, Rigamonti A, Chin DH, et al. (July 2025). "Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma". Cell Reports. 44 (7) 115951. doi:10.1016/j.celrep.2025.115951. PMID 40664206.
- ↑ Nakamura T, Sanda T (July 2025). "Non-canonical role of RCoR2: The repressor turns activator". Cell Reports. 44 (7) 115946. doi:10.1016/j.celrep.2025.115946. PMID 40664205.
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