Protodesnitazene

Protodesnitazene
Identifiers
	IUPAC name N,N-diethyl-2-[2-[(4-propoxyphenyl)methyl]benzimidazol-1-yl]ethanamine;
CAS Number	805212-21-9;
PubChem CID	157010653;
ChemSpider	129433206;
UNII	3U89F8KB95;
Chemical and physical data
Formula	C23H31N3O
Molar mass	365.521 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCOC1=CC=C(C=C1)CC2=NC3=CC=CC=C3N2CCN(CC)CC;
	InChI InChI=1S/C23H31N3O/c1-4-17-27-20-13-11-19(12-14-20)18-23-24-21-9-7-8-10-22(21)26(23)16-15-25(5-2)6-3/h7-14H,4-6,15-18H2,1-3H3; Key:CEHFMRGBRNNSCM-UHFFFAOYSA-N;

Protodesnitazene is a benzimidazole derivative which has been sold as a designer drug, and has potent opioid effects. It has been identified in Canada, Australia, the United Kingdom and Finland, first appearing in early 2025.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

References

↑ "High Risk Substance Detected In Fentanyl Trafficking Investigation". Sarnia Police Service. 13 March 2025. Retrieved 17 August 2025.
↑ "Fredericton Police Warn of New, Potentially Fatal Street Drug". City of Fredericton. Fredericton Police. 9 April 2025. Retrieved 17 August 2025.
↑ "New nitazene (strong opioid) Protodesnitazene detected" (PDF). Queensland Health. Queensland Government. March 2025. Retrieved 17 August 2025.
↑ Gwynn L (4 April 2025). "Nitazines found in black market vapes as criminals make new variations to evade detection". ABC News. Australian Broadcasting Corporation. Retrieved 17 August 2025.
↑ "Rapid Action Drug Alerts and Response (RADAR) Alert: Nitazenes". Public Health Scotland. NHS Scotland. 12 August 2025. Retrieved 17 August 2025.
↑ "Customs warns about an extremely dangerous substance in the drug trade". Finnish Customs. 20 October 2025. Retrieved 22 August 2025.
↑ Clayton J, Shi L, Robertson MJ, Skiniotis G, Michaelides M, Stavitskaya L, et al. (August 2025). "A putative binding model of nitazene derivatives at the μ-opioid receptor". Neuropharmacology. 273 110437. doi:10.1016/j.neuropharm.2025.110437. PMC 12279083. PMID 40185362.
↑ Hardwick EK, Couch AN, Davidson JT (March 2026). "Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool". Rapid Communications in Mass Spectrometry. 40 (5) e70004. doi:10.1002/rcm.70004. PMID 41359886.

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[1] "High Risk Substance Detected In Fentanyl Trafficking Investigation". Sarnia Police Service. 13 March 2025. Retrieved 17 August 2025.

[2] "Fredericton Police Warn of New, Potentially Fatal Street Drug". City of Fredericton. Fredericton Police. 9 April 2025. Retrieved 17 August 2025.

[3] "New nitazene (strong opioid) Protodesnitazene detected" (PDF). Queensland Health. Queensland Government. March 2025. Retrieved 17 August 2025.

[4] Gwynn L (4 April 2025). "Nitazines found in black market vapes as criminals make new variations to evade detection". ABC News. Australian Broadcasting Corporation. Retrieved 17 August 2025.

[5] "Rapid Action Drug Alerts and Response (RADAR) Alert: Nitazenes". Public Health Scotland. NHS Scotland. 12 August 2025. Retrieved 17 August 2025.

[6] "Customs warns about an extremely dangerous substance in the drug trade". Finnish Customs. 20 October 2025. Retrieved 22 August 2025.

[7] Clayton J, Shi L, Robertson MJ, Skiniotis G, Michaelides M, Stavitskaya L, et al. (August 2025). "A putative binding model of nitazene derivatives at the μ-opioid receptor". Neuropharmacology. 273 110437. doi:10.1016/j.neuropharm.2025.110437. PMC 12279083. PMID 40185362.

[8] Hardwick EK, Couch AN, Davidson JT (March 2026). "Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool". Rapid Communications in Mass Spectrometry. 40 (5) e70004. doi:10.1002/rcm.70004. PMID 41359886.

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Protodesnitazene

See also

References