Neurocalcin

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Structures	Swiss-model
Domains	InterPro

neurocalcin delta
neurocalcin delta
Identifiers
Symbol	NCALD
NCBI gene	83988
HGNC	7655
OMIM	606722
RefSeq	NM_001040628
UniProt	P61601
Other data
Locus	Chr. 8 q22-q23
Structures
Search for
Structures	Swiss-model
Domains	InterPro

NCALD
Identifiers
Aliases	NCALD, neurocalcin delta
External IDs	OMIM: 606722; MGI: 1196326; HomoloGene: 49978; GeneCards: NCALD; OMA:NCALD - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BJF
Gene location (Human)
Chr.	Chromosome 8 (human)
End	102,124,907 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	37,792,570 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; primary visual cortex; ; orbitofrontal cortex; ; Brodmann area 46; ; middle temporal gyrus; ; dorsolateral prefrontal cortex; ; right frontal lobe; ; Brodmann area 23; ; superior frontal gyrus;
	Top expressed in
	lateral septal nucleus; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary motor cortex; ; ventromedial nucleus; ; visual cortex; ; primary visual cortex; ; amygdala; ; prefrontal cortex; ; piriform cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	tubulin binding; clathrin binding; calcium ion binding; actin binding; alpha-tubulin binding; protein binding; metal ion binding; ligand-gated ion channel activity;
Cellular component	cytosol; intracellular anatomical structure; clathrin coat of trans-Golgi network vesicle;
Biological process	vesicle-mediated transport; calcium-mediated signaling; regulation of systemic arterial blood pressure; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	83988
	52589
	ENSG00000104490
	ENSMUSG00000051359
	P61601
	Q91X97
NM_001040624; NM_001040625; NM_001040626; NM_001040627; NM_001040628;
	NM_001040629; NM_001040630; NM_032041
NM_001170866; NM_001170867; NM_001170868; NM_134094; NM_001359839;
	NM_001359840; NM_001359841; NM_001359842; NM_001359843; NM_001359844; NM_001359845
NP_001035714; NP_001035715; NP_001035716; NP_001035717; NP_001035718;
	NP_001035719; NP_001035720; NP_114430
NP_001164337; NP_001164338; NP_001164339; NP_598855; NP_001346768;
	NP_001346769; NP_001346770; NP_001346771; NP_001346772; NP_001346773; NP_001346774
	Wikidata
View/Edit Human	View/Edit Mouse

Neurocalcin delta is a neuronal calcium-binding protein which in humans is encoded by the NCALD gene. Neurocalcin belongs to the neuronal calcium sensor (NCS) family of proteins.^[5]^[6] It expressed in mammalian brains. It possesses a Ca²⁺/myristoyl switch

The subclass of neurocalcins are brain-specific proteins that fit into the EF-hand superfamily of calcium binding proteins. The NCS family were defined by the photoreceptor cell-specific protein, recoverin. Neurocalcin was purified from the bovine brain by using calcium-dependent drug affinity chromatography. The amino acid sequence showed that neurocalcin has three functional calcium binding sites. It is expressed in the central nervous system, retina, and adrenal gland. With this unique pattern of expression it is thought that neurcalcin offers a different physiological role than similar proteins visinin and recoverin.

Neurocalcin delta an isoform of Neurocalcin is known to regulate adult neurogenesis.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104490 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051359 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Burgoyne RD (March 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
↑ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends in Neurosciences. 27 (4): 203–209. doi:10.1016/j.tins.2004.01.010. PMID 15046879. S2CID 24156457.
↑ Upadhyay A, Hosseinibarkooie S, Schneider S, Kaczmarek A, Torres-Benito L, Mendoza-Ferreira N, et al. (2019). "Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological". Frontiers in Molecular Neuroscience. 12 19. doi:10.3389/fnmol.2019.00019. PMC 6396726. PMID 30853885.

External links

Neurocalcin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
NCS proteins
Protein Database Page

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104490 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051359 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Burgoyne_2007-5] Burgoyne RD (March 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

[Burgoyne_2004-6] Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends in Neurosciences. 27 (4): 203–209. doi:10.1016/j.tins.2004.01.010. PMID 15046879. S2CID 24156457.

[7] Upadhyay A, Hosseinibarkooie S, Schneider S, Kaczmarek A, Torres-Benito L, Mendoza-Ferreira N, et al. (2019). "Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological". Frontiers in Molecular Neuroscience. 12 19. doi:10.3389/fnmol.2019.00019. PMC 6396726. PMID 30853885.

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Neurocalcin

References

Further reading

External links