// Workers AI · dad joke modeWhat did MMP24 say to MMP25? You're one byte ahead.

MMP24
Identifiers
Aliases	MMP24, MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5, matrix metallopeptidase 24
External IDs	OMIM: 604871; MGI: 1341867; HomoloGene: 21331; GeneCards: MMP24; OMA:MMP24 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.22 Start 35,226,690 bp End 35,276,998 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H1|2 77.26 cM Start 155,617,262 bp End 155,660,286 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum tendon of biceps brachii buccal mucosa cell cerebellar vermis internal globus pallidus prefrontal cortex right frontal lobe pars reticulata paraflocculus of cerebellum ganglionic eminence Top expressed in cerebellar cortex lobe of cerebellum cerebellar vermis gastrula supraoptic nucleus dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus ganglionic eminence ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding cadherin binding metal ion binding peptidase activity enzyme activator activity metalloendopeptidase activity hydrolase activity metallopeptidase activity Cellular component integral component of membrane Golgi apparatus trans-Golgi network membrane membrane extracellular matrix plasma membrane integral component of plasma membrane extracellular region extracellular exosome extracellular space Biological process glial cell differentiation proteolysis detection of temperature stimulus involved in sensory perception of pain neuronal stem cell population maintenance cell-cell adhesion mediated by cadherin cell adhesion positive regulation of catalytic activity cell-cell adhesion via plasma-membrane adhesion molecules extracellular matrix organization collagen catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10893 17391 Ensembl ENSG00000125966 ENSMUSG00000027612 UniProt Q9Y5R2 Q9R0S2 RefSeq (mRNA) NM_006690 NM_010808 RefSeq (protein) NP_006681 NP_034938 Location (UCSC) Chr 20: 35.23 – 35.28 Mb Chr 2: 155.62 – 155.66 Mb PubMed search
Wikidata
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Matrix metalloproteinase-24 is an enzyme that in humans is encoded by the MMP24 gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.

Further reading

• Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448.
• Kinoh H, Hayashita H, Kajita M, et al. (2000). "Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2→q12, respectively, by radiation hybrid and in situ hybridization". Cytogenet. Cell Genet. 87 (1–2): 97–8. doi:10.1159/000015402. PMID 10640822. S2CID 24060884.
• Romanic AM, Burns-Kurtis CL, Ao Z, et al. (2001). "Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients". Am. J. Physiol. Renal Physiol. 281 (2): F309–17. doi:10.1152/ajprenal.2001.281.2.F309. PMID 11457723. S2CID 5735565.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jung M, Römer A, Keyszer G, et al. (2003). "mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue". Prostate. 55 (2): 89–98. doi:10.1002/pros.10194. PMID 12661033. S2CID 21596144.
• Takino T, Koshikawa N, Miyamori H, et al. (2003). "Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases". Oncogene. 22 (30): 4617–26. doi:10.1038/sj.onc.1206542. hdl:2297/2668. PMID 12879005. S2CID 10007952.
• Wang P, Wang X, Pei D (2004). "Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV". J. Biol. Chem. 279 (19): 20461–70. doi:10.1074/jbc.M400264200. PMID 14990567.
• Gaetje R, Holtrich U, Engels K, et al. (2008). "Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis". Gynecol. Endocrinol. 23 (10): 567–73. doi:10.1080/09513590701556921. PMID 17952761. S2CID 25621136.