ADAM33

ADAM33
Identifiers
Aliases	ADAM33, C20orf153, DJ964F7.1, ADAM metallopeptidase domain 33
External IDs	OMIM: 607114; MGI: 1341813; HomoloGene: 11881; GeneCards: ADAM33; OMA:ADAM33 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1R54, 1R55
Gene location (Human)
Chr.	Chromosome 20 (human)
End	3,682,246 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	130,905,734 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; body of uterus; ; left uterine tube; ; stromal cell of endometrium; ; muscle layer of sigmoid colon; ; ectocervix; ; gastric mucosa; ; Descending thoracic aorta; ; ascending aorta; ; myometrium;
	Top expressed in
	ascending aorta; ; aortic valve; ; lip; ; umbilical cord; ; sciatic nerve; ; dermis; ; tunica media of zone of aorta; ; muscle of thigh; ; embryo; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; metalloendopeptidase activity; protein binding; hydrolase activity; metallopeptidase activity; metal ion binding; zinc ion binding;
Cellular component	integral component of membrane; membrane;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	80332
	110751
	ENSG00000149451
	ENSMUSG00000027318
	Q9BZ11; Q08AM2
	Q923W9
	NM_001282447; NM_025220; NM_153202
	NM_001163529; NM_033615
	NP_001269376; NP_079496; NP_694882
	NP_001157001; NP_291093
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.^[5]^[6]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness.^[7] Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149451 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027318 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, et al. (January 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–236. doi:10.1016/S0378-1119(01)00818-6. PMID 11814695.
1 2 "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33".
↑ Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, et al. (2016-07-21). "Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life". JCI Insight. 1 (11). doi:10.1172/jci.insight.87632. ISSN 0021-9738. PMC 4968941. PMID 27489884.

Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, et al. (August 2004). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical Reviews in Allergy & Immunology. 27 (1): 23–34. doi:10.1385/CRIAI:27:1:023. PMID 15347848. S2CID 23971367.
Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST (August 2004). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert Reviews in Molecular Medicine. 6 (17): 1–12. doi:10.1017/S1462399404007963. PMID 15387895. S2CID 30427584.
Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, et al. (July 2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society. 3 (5): 440–443. doi:10.1513/pats.200603-026AW. PMID 16799089.
Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. (July 2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature. 418 (6896): 426–430. doi:10.1038/nature00878. PMID 12110844. S2CID 4424215.
Garlisi CG, Zou J, Devito KE, Tian F, Zhu FX, Liu J, et al. (January 2003). "Human ADAM33: protein maturation and localization". Biochemical and Biophysical Research Communications. 301 (1): 35–43. doi:10.1016/S0006-291X(02)02976-5. PMID 12535637.
Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". Journal of Human Genetics. 48 (5): 278–281. doi:10.1007/s10038-003-0019-1. PMID 12768445.
Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, et al. (October 2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". The Journal of Allergy and Clinical Immunology. 112 (4): 717–722. doi:10.1016/s0091-6749(03)01939-0. PMID 14564349.
Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, et al. (January 2004). "Crystal structure of the catalytic domain of human ADAM33". Journal of Molecular Biology. 335 (1): 129–137. doi:10.1016/j.jmb.2003.10.037. PMID 14659745.
Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, et al. (March 2004). "Catalytic activity of human ADAM33". The Journal of Biological Chemistry. 279 (11): 9818–9830. doi:10.1074/jbc.M309696200. PMID 14676211.
Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE (July 2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". American Journal of Respiratory Cell and Molecular Biology. 31 (1): 13–21. doi:10.1165/rcmb.2003-0330OC. PMID 14742294.
Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, et al. (May 2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". American Journal of Respiratory and Critical Care Medicine. 171 (9): 958–965. doi:10.1164/rccm.200409-1251OC. PMID 15709049.
Zou J, Zhang R, Zhu F, Liu J, Madison V, Umland SP (March 2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry. 44 (11): 4247–4256. doi:10.1021/bi0476230. PMID 15766253.
Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, et al. (July 2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". American Journal of Respiratory and Critical Care Medicine. 172 (1): 55–60. doi:10.1164/rccm.200412-1708OC. PMID 15805180.

External links

The MEROPS online database for peptidases and their inhibitors: M12.244
Human ADAM33 genome location and ADAM33 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149451 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027318 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Yoshinaka_2002-5] Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, et al. (January 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–236. doi:10.1016/S0378-1119(01)00818-6. PMID 11814695.

[entrez-6] 1 2 "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33".

[7] Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, et al. (2016-07-21). "Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life". JCI Insight. 1 (11). doi:10.1172/jci.insight.87632. ISSN 0021-9738. PMC 4968941. PMID 27489884.

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v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pappalysin-1 Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

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ADAM33

Function

References

Further reading

External links