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ETFELA

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From Wikipedia, the free encyclopedia
ETFELA
Clinical data
Other namesTRALA-06; TRALA06; LA-CH2CF3; N-Ethyl-N-(2,2,2-trifluoroethyl)lysergamide
Drug classSerotonin receptor modulator
Identifiers
  • (6aR,9R)-N-Ethyl-7-methyl-N-(2,2,2-trifluoroethyl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H22F3N3O
Molar mass377.411 g·mol−1
3D model (JSmol)
  • CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC(F)(F)F
  • InChI=1S/C20H22F3N3O/c1-3-26(11-20(21,22)23)19(27)13-7-15-14-5-4-6-16-18(14)12(9-24-16)8-17(15)25(2)10-13/h4-7,9,13,17,24H,3,8,10-11H2,1-2H3/t13-,17-/m1/s1
  • Key:VAHPXTJQSWECIC-CXAGYDPISA-N

ETFELA, also known as TRALA-06 or as N-ethyl-N-(2,2,2-trifluoroethyl)lysergamide, is an analogue of lysergic acid diethylamide (LSD) first synthesized by Jason C. Parrish as part of the research team led by David E. Nichols. In studies in vitro, it was found to be slightly more potent than LSD itself.[1][2]

Chemistry

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Analogues

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Analogues of ETFELA include LSD, EcPLA, EiPLA, MiPLA, FLUORETH-LAD (FE-LAD), and FP-LAD, among others.

See also

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References

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  1. ↑ Nichols DE (2012). "Structure-activity relationships of serotonin 5-HT2A agonists". Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1 (5): 559–579. doi:10.1002/wmts.42.
  2. ↑ Nichols DE (2017). "Chemistry and Structure-Activity Relationships of Psychedelics". Behavioral Neurobiology of Psychedelic Drugs. Current Topics in Behavioral Neurosciences. Vol. 36. pp. 1–43. doi:10.1007/7854_2017_475. ISBN 978-3-662-55878-2. PMID 28401524. S2CID 4396184.
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