DNAJC7

DNAJC7
Identifiers
Aliases	DNAJC7, DJ11, DJC7, TPR2, TTC2, DnaJ heat shock protein family (Hsp40) member C7
External IDs	OMIM: 601964; MGI: 1928373; GeneCards: DNAJC7
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,021,376 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,511,014 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; right frontal lobe; ; anterior pituitary; ; monocyte; ; mucosa of transverse colon; ; apex of heart; ; cingulate gyrus; ; Brodmann area 9; ; anterior cingulate cortex;
	Top expressed in
	tail of embryo; ; neural layer of retina; ; ventricular zone; ; genital tubercle; ; superior frontal gyrus; ; thymus; ; ganglionic eminence; ; cerebellar cortex; ; primary visual cortex; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; heat shock protein binding; ATPase activator activity;
Cellular component	cytoplasm; extracellular exosome; cytoskeleton; membrane; nucleus; nucleoplasm; cytosol;
Biological process	regulation of cellular response to heat; protein folding; positive regulation of ATP-dependent activity; chaperone cofactor-dependent protein refolding;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7266
	56354
	ENSG00000168259
	ENSMUSG00000014195
	Q99615
	Q9QYI3
	NM_001144766; NM_003315
	NM_019795; NM_001378962; NM_001378963
	NP_001138238; NP_003306
	NP_062769; NP_001365891; NP_001365892
	Wikidata
View/Edit Human	View/Edit Mouse

DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.^[5]^[6]^[7]

Interactions

DNAJC7 has been shown to interact with RAD9A.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168259 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014195 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". DNA Cell Biol. 15 (9): 727–35. doi:10.1089/dna.1996.15.727. PMID 8836031.
↑ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 12 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
↑ "Entrez Gene: DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7".
↑ Xiang SL, Kumano T, Iwasaki SI, Sun X, Yoshioka K, Yamamoto KC (2001). "The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9". Biochem. Biophys. Res. Commun. 287 (4): 932–40. doi:10.1006/bbrc.2001.5685. hdl:2297/1794. PMID 11573955. S2CID 20694221.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Xiang SL, Kumano T, Iwasaki SI, et al. (2001). "The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9". Biochem. Biophys. Res. Commun. 287 (4): 932–40. doi:10.1006/bbrc.2001.5685. hdl:2297/1794. PMID 11573955. S2CID 20694221.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brychzy A, Rein T, Winklhofer KF, et al. (2003). "Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system". EMBO J. 22 (14): 3613–23. doi:10.1093/emboj/cdg362. PMC 165632. PMID 12853476.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168259 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014195 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8836031-5] Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". DNA Cell Biol. 15 (9): 727–35. doi:10.1089/dna.1996.15.727. PMID 8836031.

[pmid11147971-6] Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 12 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)

[entrez-7] "Entrez Gene: DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7".

[pmid11573955-8] Xiang SL, Kumano T, Iwasaki SI, Sun X, Yoshioka K, Yamamoto KC (2001). "The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9". Biochem. Biophys. Res. Commun. 287 (4): 932–40. doi:10.1006/bbrc.2001.5685. hdl:2297/1794. PMID 11573955. S2CID 20694221.

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DNAJC7

Interactions

References

Further reading