UBA6

UBA6
Identifiers
Aliases	UBA6, E1-L2, MOP-4, UBE1L2, ubiquitin like modifier activating enzyme 6
External IDs	OMIM: 611361; MGI: 1913894; GeneCards: UBA6
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,701,155 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,320,662 bp
RNA expression pattern
	Top expressed in
	oocyte; ; epithelium of nasopharynx; ; Achilles tendon; ; gingival epithelium; ; germinal epithelium; ; mucosa of paranasal sinus; ; endothelial cell; ; ventricular zone; ; corpus callosum; ; oral cavity;
	Top expressed in
	otic vesicle; ; hand; ; spermatogonium; ; trigeminal ganglion; ; primitive streak; ; superior cervical ganglion; ; otolith organ; ; maxillary prominence; ; utricle; ; pineal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	FAT10 activating enzyme activity; nucleotide binding; ligase activity; protein binding; ATP binding; ubiquitin-like modifier activating enzyme activity; ubiquitin activating enzyme activity;
Cellular component	cytosol; cytoplasm;
Biological process	dendritic spine development; amygdala development; learning; hippocampus development; ubiquitin-dependent protein catabolic process; locomotory behavior; protein ubiquitination; cellular response to DNA damage stimulus; protein modification by small protein conjugation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55236
	231380
	ENSG00000033178
	ENSMUSG00000035898
	A0AVT1; H0Y9U5
	Q8C7R4
	NM_018227
	NM_172712
	NP_060697
	NP_766300
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-like modifier-activating enzyme 6 is an enzyme that in humans is encoded by the UBA6 gene (previously UBE1L2).^[5]^[6] This enzyme functions to activate ubiquitin through adenylation.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000033178 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035898 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Pelzer C, Kassner I, Matentzoglu K, Singh RK, Wollscheid HP, Scheffner M, Schmidtke G, Groettrup M (Aug 2007). "UBE1L2, a novel E1 enzyme specific for ubiquitin". J Biol Chem. 282 (32): 23010–4. doi:10.1074/jbc.C700111200. PMID 17580310.
↑ "Entrez Gene: UBE1L2 ubiquitin-activating enzyme E1-like 2".
↑ "Ubiquitin-like modifier-activating enzyme 6". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhu H, Zhou ZM, Huo R, et al. (2004). "Identification and characteristics of a novel E1 like gene nUBE1L in human testis". Acta Biochim. Biophys. Sin. (Shanghai). 36 (3): 227–34. doi:10.1093/abbs/36.3.227. PMID 15202508.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Jin J, Li X, Gygi SP, Harper JW (2007). "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging". Nature. 447 (7148): 1135–8. Bibcode:2007Natur.447.1135J. doi:10.1038/nature05902. PMID 17597759. S2CID 4337767.
Chiu YH, Sun Q, Chen ZJ (2007). "E1-L2 activates both ubiquitin and FAT10". Mol. Cell. 27 (6): 1014–23. doi:10.1016/j.molcel.2007.08.020. PMID 17889673.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000033178 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035898 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17580310-5] Pelzer C, Kassner I, Matentzoglu K, Singh RK, Wollscheid HP, Scheffner M, Schmidtke G, Groettrup M (Aug 2007). "UBE1L2, a novel E1 enzyme specific for ubiquitin". J Biol Chem. 282 (32): 23010–4. doi:10.1074/jbc.C700111200. PMID 17580310.

[entrez-6] "Entrez Gene: UBE1L2 ubiquitin-activating enzyme E1-like 2".

[uniprot-7] "Ubiquitin-like modifier-activating enzyme 6". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

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UBA6

References

Further reading