// Workers AI · dad joke modeWhat did CL 110,393 say to CL 110,392? "You're one byte behind.

CL 110,393
Chemical and physical data
Formula	C32H32ClN3O3
Molar mass	542.08 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1cccc(c1)n1nccc1[C@H]1C[C@]23C=C[C@]1(OC)[C@@H]1Oc4c(O)ccc5C[C@H]2N(CC[C@]13c54)CC1CC1;

CL 110,393 is an opioid drug derived from thebaine, closely related to the family of drugs known as the Bentley compounds which includes better known examples such as buprenorphine, etorphine and diprenorphine. Unlike most other related compounds, CL 110,393 acts as a highly selective κ-opioid receptor agonist with negligible activity at the μ-opioid receptor. It produces hallucinogenic effects with high potency and a long duration of action, as well as side effects such as dysphoria, tinnitus, slurred speech, ataxia, perspiration and tingling of the skin, and was investigated as a non-lethal incapacitating agent.^[1]^[2]^[3]

References

↑ Martin WR (1967). "Opioid Antagonists". Pharmacological Reviews. 19 (4): 463–521. doi:10.1016/S0031-6997(25)07161-3.
↑ Eddy NB, Martin WR (1970). "Drug Dependence of Specific Opiate Antagonist Type". Pharmacopsychiatry. 3 (2): 73–82. doi:10.1055/s-0028-1094264.
↑ Angrist B, Gershon S (May 1973). "Behavioral profile of a potent new psychotoxic compound". Psychopharmacologia. 30 (2): 109–116. doi:10.1007/BF00421425. PMID 4711368.

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[Martin_1967-1] Martin WR (1967). "Opioid Antagonists". Pharmacological Reviews. 19 (4): 463–521. doi:10.1016/S0031-6997(25)07161-3.

[Eddy_1970-2] Eddy NB, Martin WR (1970). "Drug Dependence of Specific Opiate Antagonist Type". Pharmacopsychiatry. 3 (2): 73–82. doi:10.1055/s-0028-1094264.

[Angrist_1973-3] Angrist B, Gershon S (May 1973). "Behavioral profile of a potent new psychotoxic compound". Psychopharmacologia. 30 (2): 109–116. doi:10.1007/BF00421425. PMID 4711368.

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v t e Hallucinogens
Psychedelics (5-HT_2A agonists)	Tryptamines (e.g., DMT, psilocin, psilocybin, bufotenin, 5-MeO-DMT, AMT) Phenethylamines (e.g., mescaline, 2C-B, DOM, MDA, TMA, 2C-B-FLY, 25I-NBOMe) Lysergamides (e.g., LSD, ergine, isoergine) Others (e.g., efavirenz, glaucine, IHCH-7113, MK-212, quipazine, RH-34) For a full list of serotonergic psychedelics, see the navbox here and the list here instead.
Dissociatives (NMDA antagonists)	Arylcyclohexylamines (e.g., ketamine (K), phencyclidine (PCP), methoxetamine (MXE), tiletamine) Adamantanes (e.g., memantine, amantadine) Diarylethylamines (e.g., diphenidine, ephenidine, methoxphenidine) Morphinans (e.g., dextromethorphan (DXM), dextrorphan (DXO)) Inhalants (e.g., nitrous oxide (N₂O), xenon (Xe)) Others (e.g., alkyl nitrites/poppers, aptiganel, dexoxadrol, dizocilpine (MK-801), etoxadrol, selfotel) For a full list of dissociatives, see the navbox here instead.
Deliriants (mACh antagonists)	Tropanes: Atropine Hyoscyamine Scopolamine (hyoscine) Antihistamines: Brompheniramine Chloropyramine Chlorphenamine (chlorpheniramine) Clemastine Cyclizine Cyproheptadine Dimenhydrinate Diphenhydramine Doxylamine Meclizine Mepyramine Pheniramine Phenyltoloxamine Promethazine Tripelennamine Triprolidine Others: Benactyzine Benapryzine (benaprizine) Benzatropine (benztropine) Biperiden BZ (QNB) CAR-226,086 CAR-301,060 CAR-302,196 CAR-302,282 CAR-302,668 CS-27349 Cycrimine Dicycloverine Ditran (JB-329) EA-3167 EA-3443 EA-3580 EA-3834 Flavoxate JB-318 JB-336 Orphenadrine Oxybutynin Procyclidine Tolterodine Trihexyphenidyl Tropicamide Tropine benzilate WIN-2299
KOR agonists	Salvinoids (terpenoids): 2-EMSB 2-MMSB RB-64 (22-thiocyanatosalvinorin A) Salvinorin A Benzomorphans: Alazocine Bremazocine Cyclazocine Ketazocine Metazocine MR-2034 Pentazocine Phenazocine Morphinans: Butorphanol Cyclorphan Cyprenorphine Diprenorphine Heroin Levallorphan Levomethorphan Levorphanol Morphine Nalbuphine Nalmefene Nalorphine Oxilorphan Proxorphan Racemethorphan Racemorphan Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom
GABA_A agonists	Isoxazoles: Gaboxadol (THIP) Ibotenic acid (Amanita muscaria) Muscimol (Amanita muscaria) Indirect GABA_A receptor agonists: GABA_A receptor positive allosteric modulators (nonbenzodiazepines/Z-drugs) (e.g., eszopiclone, zaleplon, zolpidem, zopiclone) GABA reuptake inhibitors (e.g., CI-966)
Oneirogens (unknown mech.)	Harmala alkaloids/β-carbolines (e.g., harmine, harmaline, tetrahydroharmine, 6-methoxyharmalan, 6-MeO-THH) (found in Peganum harmala, Banisteriopsis caapi) Iboga alkaloids/azepinoindoles (e.g., ibogaine, noribogaine) (found in Tabernanthe iboga)
Cannabinoids (CB₁ agonists)	Phytocannabinoids (e.g., Δ⁹-THC (dronabinol), CBN, Δ⁸-THC) Synthetic cannabinoids (e.g., nabilone, JWH-018, JWH-073, HU-210) For a full list of cannabinoids, see the navbox here and the list here instead.
Others	Aminochromes (e.g., adrenochrome, adrenolutin) Carbogen Glaucine Hallucinogenic bolete mushrooms (e.g., Lanmaoa asiatica) Hallucinogenic fish (ichthyoallyeinotoxism) Icelandic hallucinogenic lichen ("rock soup") Jenkem Kambo (sapo; Phyllomedusa bicolor skin secretions) Kykeon (Eleusinian Mysteries) Mad honey (Rhododendron; grayanotoxins) Nutmeg (e.g., myristicin, elemicin) Sinicuichi (e.g., cryogenine) Soma (haoma) Hallucinogen combinations (e.g., ayahuasca, teotlaqualli) Others (e.g., insect hallucinogens)
See also: Psychedelics Dissociatives Entactogens Stimulants Depressants List of hallucinogens

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See also

References