// Workers AI · dad joke modeWhat did AMY1C say to its friend? "You're a-maize-ing.

AMY1C
Identifiers
Aliases	AMY1C, AMY1, amylase, alpha 1C (salivary), amylase alpha 1C (salivary), amylase alpha 1C
External IDs	OMIM: 104702; GeneCards: AMY1C
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	103,758,726 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; testicle; ; olfactory zone of nasal mucosa; ; gonad; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of pancreas; ; right lung; ; upper lobe of left lung; ; left testis;
	n/a
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	278
	n/a
	ENSG00000187733
	n/a
	P0DTE8
	n/a
	NM_001008219; NM_001346780
	n/a
	NP_001008220; NP_001333709
	n/a
	Wikidata
View/Edit Human

Alpha-amylase 1C is a digestive enzyme that in humans is encoded by the gene AMY1C. ^[3]^[4] This saliva enzyme functions to initiate the break down of starch and other carbohydrates.^[5] AMY1C is one of a collection of nearby human genes (including AMY1A and AMY1B) that encode identical saliva alpha-amylase proteins, with the exact number of genes varying from individual to individual.^[5]^[6]

Function

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either the salivary glands (AMY1A, AMY1B, AMY1C)^[6] or pancreas (AMY2A, AMY2B).^[6] This gene encodes an amylase isoenzyme produced by the salivary gland.^[3] See also Amylase § Evolution.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187733 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Amylase, alpha 1C (salivary)". Retrieved 2013-02-14.
↑ Hariharan R, Mousa A, de Courten B (June 2021). "Influence of AMY1A copy number variations on obesity and other cardiometabolic risk factors: A review of the evidence". Obesity Reviews. 22 (6) e13205. doi:10.1111/obr.13205. PMID 33432778.
1 2 "Alpha-amylase 1C". uniprot.org. UniProt consortium. Retrieved 2026-09-13.
1 2 3 Butterworth PJ, Warren FJ, Ellis PR (July 2011). "Human α‐amylase and starch digestion: An interesting marriage". Starch‐Stärke. 63 (7): 395–405. doi:10.1002/star.201000150.

External links

Overview of all the structural information available in the PDB for UniProt: P04745 (Human Alpha-amylase 1) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187733 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "Entrez Gene: Amylase, alpha 1C (salivary)". Retrieved 2013-02-14.

[Hariharan_2021-4] Hariharan R, Mousa A, de Courten B (June 2021). "Influence of AMY1A copy number variations on obesity and other cardiometabolic risk factors: A review of the evidence". Obesity Reviews. 22 (6) e13205. doi:10.1111/obr.13205. PMID 33432778.

[uniprot-5] 1 2 "Alpha-amylase 1C". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

[Butterworth2011-6] 1 2 3 Butterworth PJ, Warren FJ, Ellis PR (July 2011). "Human α‐amylase and starch digestion: An interesting marriage". Starch‐Stärke. 63 (7): 395–405. doi:10.1002/star.201000150.

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// Workers AI · dad joke modeWhat did AMY1C say to its friend? "You're a-maize-ing.

Function

References

External links