Talk:Kenneth Zaret

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Birch1986 (talk · contribs) This user has declared a connection. (https://en.wikipedia.org/wiki/Kenneth_Zaret)

COI tag (July 2023)

Latest comment: 3 years ago1 comment1 person in discussion

User:Birch1896 (formerly User:Irmupenn) is somehow connected to the Institute for Regenerative Medicine at Univ of Penn, where Zaret is the director. UtherSRG (talk) 11:45, 1 July 2023 (UTC)Reply

Please add information to my biography

Latest comment: 1 year ago1 comment1 person in discussion

Based on what I have seen written about me in a manuscript I reviewed for Science magazine, below are additions to my biography that better highlight my contributions to the field. Thank you very much for taking the time.

Career:

- please delete the word "some" on line 2. I find the word vague and usually avoid it.

Research:

- paragraph 3, please add the following sentences in the middle, between the two existing sentences ending with "to turn on." and "The mechanism..."

"He discovered that the basis for pioneering is the ability of certain transcription factors to target DNA sites on nucleosomes, which are the primary means of packaging DNA in chromosomes (new ref. 15). Zaret's team found that FoxA and GATA transcription factors occupy silent gene sites in undifferentiated embryonic cells, helping to impart the competence to activate tissue-specific genes and initiate tissue development (new refs 16, 17)."

new ref. 15:

Cirillo, Lisa A.; McPherson, Clifton E.; Bossard, Pascale; Stevens, Kimberly; Cherian, Sindhu; Shim, Eun-Yong; Clark, Kirk L.; Burley, Stephen K.; Zaret, Kenneth S. (January 2, 1998). "Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome" EMBO Journal 17: 244-254. PMID 9427758 DOI: 10.1093/emboj/17.1.244

new ref. 16:

Gualdi, Rossana; Bossard, Pascale; Zheng, Minghua; Hamada, Yoshio; Coleman, John; Zaret, Kenneth S. (July 1, 1996) "Hepatic specification of the gut endoderm in vitro: Cell signaling and transcriptional control." Genes and Development 10: 1670-1682. PMID: 8682297 doi: 10.1101/gad.10.13.1670

new ref. 17:

Bossard, Pascale; Zaret, Kenneth. S. (December 1998) "GATA transcription factors as potentiators of gut endoderm differentiation." Development 125, 4909-4917. PMID: 9811575 doi: 10.1242/dev.125.24.4909 Mobi777 (talk) 19:16, 30 April 2025 (UTC)Reply