Mycothiol synthase
| Mycothiol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.189 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Mycothiol synthase (EC 2.3.1.189, MshD) is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase.[1][2] It catalyses the following chemical reaction:
This enzyme, found in Actinomycetota and characterised from Mycobacterium tuberculosis catalyses the last step in the biosynthesis of mycothiol.[3] It is a member of a large family of GCN5-related N-acetyltransferases which transfer acetyl groups.[4]
References
[edit]- ↑ Spies HS, Steenkamp DJ (August 1994). "Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis". European Journal of Biochemistry. 224 (1): 203–13. doi:10.1111/j.1432-1033.1994.tb20013.x. PMID 8076641.
- ↑ Koledin T, Newton GL, Fahey RC (November 2002). "Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes". Archives of Microbiology. 178 (5): 331–7. Bibcode:2002ArMic.178..331K. doi:10.1007/s00203-002-0462-y. PMID 12375100.
- ↑ Vetting MW, Roderick SL, Yu M, Blanchard JS (September 2003). "Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases". Protein Science. 12 (9): 1954–9. doi:10.1110/ps.03153703. PMC 2323992. PMID 12930994.
- ↑ Enzyme 2.3.1.189 at KEGG Pathway Database.
External links
[edit]- Mycothiol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
