GSTO2

GSTO2
Identifiers
Aliases	GSTO2, GSTO 2-2, bA127L20.1, glutathione S-transferase omega 2
External IDs	OMIM: 612314; MGI: 1915464; GeneCards: GSTO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q18, 3Q19, 3QAG
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	104,304,950 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	47,874,763 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; skin of arm; ; islet of Langerhans; ; skin of abdomen; ; right testis; ; right uterine tube; ; left testis; ; skin of leg; ; anterior pituitary; ; pancreatic ductal cell;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; hair; ; morula; ; embryo; ; embryo; ; thyroid gland; ; brown adipose tissue; ; transitional epithelium of urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; oxidoreductase activity; methylarsonate reductase activity; protein binding; glutathione dehydrogenase (ascorbate) activity; identical protein binding; glutathione transferase activity;
Cellular component	cytosol; extracellular exosome; cytoplasm;
Biological process	metabolism; cellular response to arsenic-containing substance; glutathione derivative biosynthetic process; L-ascorbic acid metabolic process; xenobiotic metabolic process; cellular oxidant detoxification; glutathione metabolic process; toxin catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	119391
	68214
	ENSG00000065621
	ENSMUSG00000025069
	Q9H4Y5
	Q8K2Q2
	NM_001191013; NM_001191014; NM_001191015; NM_183239
	NM_026619; NM_030051
	NP_001177942; NP_001177943; NP_001177944; NP_899062
	NP_080895; NP_084327
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione S-transferase omega-2 is an enzyme that in humans is encoded by the GSTO2 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000065621 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025069 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID 12618591.
↑ "Entrez Gene: GSTO2 glutathione S-transferase omega 2".

White DL, Li D, Nurgalieva Z, El-Serag HB (Feb 2008). "Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis". American Journal of Epidemiology. 167 (4): 377–89. doi:10.1093/aje/kwm315. PMID 18065725.
Calarco JA, Xing Y, Cáceres M, Calarco JP, Xiao X, Pan Q, Lee C, Preuss TM, Blencowe BJ (Nov 2007). "Global analysis of alternative splicing differences between humans and chimpanzees". Genes & Development. 21 (22): 2963–75. doi:10.1101/gad.1606907. PMC 2049197. PMID 17978102.
Leite JL, Morari EC, Granja F, Campos GM, Guilhen AC, Ward LS (Mar 2007). "Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma". Revista Médica de Chile. 135 (3): 301–6. doi:10.4067/s0034-98872007000300004. PMID 17505575.
Wahner AD, Glatt CE, Bronstein JM, Ritz B (Feb 2007). "Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease". Neuroscience Letters. 413 (3): 274–8. doi:10.1016/j.neulet.2006.11.053. PMC 1864949. PMID 17194543.
Morari EC, Lima AB, Bufalo NE, Leite JL, Granja F, Ward LS (Aug 2006). "Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients". Journal of Cancer Research and Clinical Oncology. 132 (8): 521–8. doi:10.1007/s00432-006-0099-3. PMC 12161103. PMID 16788846. S2CID 12993417.
Pongstaporn W, Rochanawutanon M, Wilailak S, Linasamita V, Weerakiat S, Petmitr S (Mar 2006). "Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer". Journal of Experimental & Clinical Cancer Research. 25 (1): 107–14. PMID 16761626.
Marahatta SB, Punyarit P, Bhudisawasdi V, Paupairoj A, Wongkham S, Petmitr S (May 2006). "Polymorphism of glutathione S-transferase omega gene and risk of cancer". Cancer Letters. 236 (2): 276–81. doi:10.1016/j.canlet.2005.05.020. PMID 15992993.
Wang L, Xu J, Ji C, Gu S, Lv Y, Li S, Xu Y, Xie Y, Mao Y (Jul 2005). "Cloning, expression and characterization of human glutathione S-transferase Omega 2". International Journal of Molecular Medicine. 16 (1): 19–27. doi:10.3892/ijmm.16.1.19. PMID 15942673.
Ozturk A, Desai PP, Minster RL, Dekosky ST, Kamboh MI (2005). "Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease". Neurobiology of Aging. 26 (8): 1161–5. doi:10.1016/j.neurobiolaging.2004.11.001. PMID 15917099. S2CID 10878355.
Whitbread AK, Mellick GD, Silburn PA, Le Couteur DG, Board PG (May 2004). "Glutathione transferase Omega class polymorphisms in Parkinson disease". Neurology. 62 (10): 1910–1. doi:10.1212/01.wnl.0000125282.09308.b1. PMID 15159516. S2CID 46505059.
Arning L, Jagiello P, Wieczorek S, Saft C, Andrich J, Epplen JT (Mar 2004). "Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease". BMC Medical Genetics. 5: 7. doi:10.1186/1471-2350-5-7. PMC 394327. PMID 15040808.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000065621 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025069 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12618591-5] Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID 12618591.

[entrez-6] "Entrez Gene: GSTO2 glutathione S-transferase omega 2".

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References

Further reading