Draft:Orthomolecular Nutritional Medicine
Submission declined on 7 August 2026 by LittlePuppers (talk). This draft appears to be a duplicate of an existing article. Wikipedia does not permit multiple articles on the same topic.
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Comment: See also Special:Diff/1368087464. I will create this title in mainspace as a redirect to Orthomolecular Medicine. LittlePuppers (talk) 00:03, 7 August 2026 (UTC)
- Comment: Note that Orthomolecular medicine is described in our article as alternative medicine. There are definitely some tone issues with this draft; I am going to ask at Wikiproject Medicine for further thoughts. LittlePuppers (talk) 22:26, 6 August 2026 (UTC)
- Comment: In accordance with Wikipedia's Conflict of interest guideline, I disclose that I have a conflict of interest regarding the subject of this article. Orthomoriaki (talk) 17:27, 3 May 2026 (UTC)
Orthomolecular Nutritional Medicine is a clinical approach to health that focuses on nourishing the body at a cellular level through the optimal intake of nutrients and other factors essential for cellular renewal. Unlike approaches based on high-dose supplementation, Orthomolecular Nutritional Medicine aims to identify the ideal amounts of nutrients for each individual, based on their specific clinical profile as assessed by a certified physician.[1]
In this framework, the concept of "nutrition" extends beyond food to encompass all factors that influence cellular function, including hydration, breathing, diet, nutritional supplements, and environmental factors. The goal is to support cells in maintaining the correct molecular structure needed for healthy function.
The Five Pillars
[edit]Orthomolecular Nutritional Medicine organises its clinical approach around five foundational pillars, each addressing a key physiological domain and supported by peer-reviewed scientific research.
1. Inflammation Control and Reduction
[edit]Chronic low-grade inflammation is recognised in the scientific literature as an underlying factor in many chronic conditions. A study published in the British Journal of Nutrition (2015) found that a Western-style diet rich in fats and simple sugars but poor in micronutrients is linked to increased prevalence of diseases with immunological and autoimmune components, including allergies, atopic dermatitis and obesity.[2] Research from Newcastle University published in Nature Communications (2014) established that chronic inflammation induces telomere dysfunction and accelerates cellular ageing.[3]
2. Gastrointestinal Regulation
[edit]The gastrointestinal system plays a central role in overall health through the gut-brain axis and the gut microbiome. Research published in the Journal of Medicinal Food (2014) demonstrated that disruption of the gut microbiome may contribute to disease in the cardiovascular, immune and neurological systems beyond the digestive tract.[4] A study published in Neurogastroenterology and Motility (2013) found that individuals with depression and chronic anxiety exhibit significant disruption of the intestinal microbiome.[5]
3. Detoxification, Antioxidation and pH Regulation
[edit]Oxidative stress and the accumulation of toxins are associated with chronic disease. A study in the Journal of Nutrition (2014) reported that intake of antioxidant anthocyanins and flavones was associated with improved insulin sensitivity and reduced inflammatory markers in women.[6] Research from Maastricht University Medical Center (2014) indicated that polyphenols may help prevent metabolic syndrome and type 2 diabetes through regulation of fatty acid metabolism and mitochondrial function.[7]
4. Cellular Nutrition
[edit]Ensuring cells receive adequate micronutrients is central to this pillar. The UK National Food Survey (1997) identified widespread population deficiencies in zinc, iron and magnesium below recommended daily allowances.[8] Biochemist Bruce Ames, writing in Archives of Biochemistry and Biophysics, documented associations between deficiencies of vitamins B12, B6, B3, folic acid, E and C, as well as zinc and iron, and DNA damage — suggesting a link to accelerated ageing.[9]
5. Biochemical Stress Management
[edit]Chronic biochemical stress has measurable effects on cellular function and DNA integrity. A study published in Nature (2015) found that physiological stress induces DNA damage in haematopoietic stem cells, providing a mechanistic explanation for the accumulation of DNA damage during ageing.[10] Research published in the FASEB Journal linked vitamin D and omega-3 fatty acids to the regulation of brain serotonin synthesis and function, with implications for ADHD, bipolar disorder, schizophrenia and impulsive behaviour.[11]
See also
[edit]References
[edit]- ↑ Pauling, Linus (1968). "Orthomolecular Psychiatry: Varying the concentrations of substances normally present in the human body may control mental disease". Science. 160 (3825): 265–271. doi:10.1126/science.160.3825.265. PMID 5641253.
- ↑ Minihane, Anne M.; et al. (2015). "Low-grade inflammation, diet composition and health: current research evidence and its translation". British Journal of Nutrition. 114 (7): 999–1012. Bibcode:2015BrJN..114..999M. doi:10.1017/S0007114515002093. PMC 4579563. PMID 26228057.
- ↑ Jurk, Diana; Wilson, Caroline; Passos, João F.; Oakley, Fiona; Correia-Melo, Clara; Greaves, Laura; Saretzki, Gabriele; Fox, Chris; Lawless, Conor; Anderson, Rhys; Hewitt, Graeme; Pender, Sylvia LF; Fullard, Nicola; Nelson, Glyn; Mann, Jelena; Van De Sluis, Bart; Mann, Derek A.; von Zglinicki, Thomas (2014). "Chronic inflammation induces telomere dysfunction and accelerates ageing in mice". Nature Communications. 5 (1) 4172. Bibcode:2014NatCo...5.4172J. doi:10.1038/ncomms5172. PMC 4090717. PMID 24960204.
- ↑ Galland, Leo (2014). "The Gut Microbiome and the Brain". Journal of Medicinal Food. 17 (12): 1261–1272. doi:10.1089/jmf.2014.7000. PMC 4259177. PMID 25402818.
- ↑ Dinan, T. G.; Cryan, J. F. (2013). "Intestinal microbiota, diet and chronic psychiatric illnesses". Neurogastroenterology and Motility. 25 (9): 713–719. doi:10.1111/nmo.12198. PMID 23910373.
- ↑ Jennings, Amy; Welch, Ailsa A.; Spector, Tim; MacGregor, Alex; Cassidy, Aedín (February 2014). "Intakes of Anthocyanins and Flavones Are Associated with Biomarkers of Insulin Resistance and Inflammation in Women". Journal of Nutrition. 144 (2): 202. Bibcode:2014JNut..144..202J. doi:10.3945/jn.113.184358.
- ↑ "Polyphenols and prevention of metabolic syndrome". Current Opinion in Clinical Nutrition and Metabolic Care. Maastricht University Medical Center. 2014.
- ↑ National Food Survey 1997 (Report). London: Ministry of Agriculture, Fisheries and Food. 1998.
- ↑ Ames, Bruce N. (2004). "A role for supplements in optimizing health: the metabolic tune-up". Archives of Biochemistry and Biophysics. 423 (1): 227–234. doi:10.1016/j.abb.2003.11.002. PMID 14989256.
- ↑ Walter, D.; et al. (2015). "Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells". Nature. 520 (7548): 549–552. Bibcode:2015Natur.520..549W. doi:10.1038/nature14131. PMID 25707806.
- ↑ "Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior". FASEB Journal. 2015.