DTYMK

DTYMK
Identifiers
Aliases	DTYMK, CDC8, PP3731, TMPK, TYMK, deoxythymidylate kinase, CONPM
External IDs	OMIM: 188345; MGI: 108396; GeneCards: DTYMK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E9F, 1E9E, 1NMY, 1E2G, 1E9D, 1E98, 1E2E, 1NN0, 1E2Q, 1E9C, 1E2F, 1NN5, 1E99, 2XX3, 1NMZ, 1E9A, 1E2D, 1E9B, 1NMX, 1NN1, 1NN3
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,686,944 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,729,656 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gonad; ; mucosa of transverse colon; ; ganglionic eminence; ; stromal cell of endometrium; ; right adrenal gland; ; apex of heart; ; granulocyte; ; right adrenal cortex; ; right hemisphere of cerebellum;
	Top expressed in
	endocardial cushion; ; renal corpuscle; ; primitive streak; ; medullary collecting duct; ; Paneth cell; ; ureter; ; embryo; ; ventricular zone; ; condyle; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; uridylate kinase activity; kinase activity; thymidylate kinase activity; nucleoside monophosphate kinase activity; ATP binding; nucleoside diphosphate kinase activity;
Cellular component	mitochondrial intermembrane space; mitochondrial matrix; cytoplasm; mitochondrion; cytosol; nucleus;
Biological process	nucleobase-containing small molecule interconversion; nucleotide biosynthetic process; response to cadmium ion; phosphorylation; cellular response to growth factor stimulus; dTTP biosynthetic process; response to estrogen; dTDP biosynthetic process; dUDP biosynthetic process; myoblast differentiation; cell population proliferation; nucleoside monophosphate phosphorylation; nucleotide phosphorylation; nucleoside diphosphate phosphorylation; thymidine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1841
	21915
	ENSG00000168393
	ENSMUSG00000026281
	P23919
	P97930
NM_001165031; NM_012145; NM_001320902; NM_001320903; NM_001320904;
	NM_001320905
	NM_001105667; NM_023136
NP_001158503; NP_001307831; NP_001307832; NP_001307833; NP_001307834;
	NP_036277
	NP_001099137; NP_075625
	Wikidata
View/Edit Human	View/Edit Mouse

Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene.^[5]^[6]^[7] and belongs to thymidylate kinase family of proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168393 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026281 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Su JY, Sclafani RA (May 1991). "Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast". Nucleic Acids Res. 19 (4): 823–7. doi:10.1093/nar/19.4.823. PMC 333717. PMID 2017365.
↑ Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A (Aug 1994). "Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth". DNA Cell Biol. 13 (5): 461–71. doi:10.1089/dna.1994.13.461. PMID 8024690.
↑ "Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase)".

Van Rompay AR, Johansson M, Karlsson A (2000). "Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases". Pharmacol. Ther. 87 (2–3): 189–98. doi:10.1016/S0163-7258(00)00048-6. PMID 11008000.
Tamiya N, Yusa T, Yamaguchi Y, et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography". Biochim. Biophys. Acta. 995 (1): 28–35. doi:10.1016/0167-4838(89)90229-X. PMID 2538159.
Cummins RR, Balinsky D (1980). "Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver". Cancer Res. 40 (4): 1235–9. PMID 6244089.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ostermann N, Segura-Peña D, Meier C, et al. (2003). "Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds". Biochemistry. 42 (9): 2568–77. doi:10.1021/bi027302t. PMID 12614151.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168393 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026281 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2017365-5] Su JY, Sclafani RA (May 1991). "Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast". Nucleic Acids Res. 19 (4): 823–7. doi:10.1093/nar/19.4.823. PMC 333717. PMID 2017365.

[pmid8024690-6] Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A (Aug 1994). "Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth". DNA Cell Biol. 13 (5): 461–71. doi:10.1089/dna.1994.13.461. PMID 8024690.

[entrez-7] "Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase)".

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References

Further reading