Vestigial like family member 4

VGLL4
Identifiers
Aliases	VGLL4, VGL-4, vestigial like family member 4
External IDs	MGI: 2652840; HomoloGene: 18603; GeneCards: VGLL4; OMA:VGLL4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.3-p25.2 Start 11,556,069 bp End 11,771,350 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 E3 Start 114,837,589 bp End 114,946,955 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia nipple trigeminal ganglion pylorus retinal pigment epithelium renal medulla left ovary spinal ganglia trachea saphenous vein Top expressed in Rostral migratory stream internal carotid artery external carotid artery lip genital tubercle epithelium of lens tail of embryo ventricular zone granulocyte right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding transcription coactivator binding Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9686 232334 Ensembl ENSG00000144560 ENSMUSG00000030315 UniProt Q14135 Q80V24 RefSeq (mRNA) NM_001128219 NM_001128220 NM_001128221 NM_001284390 NM_001284391 NM_014667 NM_177683 NM_001356371 RefSeq (protein) NP_001121691 NP_001121692 NP_001121693 NP_001271319 NP_001271320 NP_055482 NP_808351 NP_001343300 Location (UCSC) Chr 3: 11.56 – 11.77 Mb Chr 6: 114.84 – 114.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Vestigial like family member 4 is a protein that in humans is encoded by the VGLL4 gene.

Further reading

• Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi:10.1074/jbc.M400154200. PMID 15140898.
• Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi:10.1074/jbc.M400154200. PMID 15140898.
• Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi:10.1074/jbc.M400154200. PMID 15140898.
• Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (December 2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
• Jin HS, Park HS, Shin JH, Kim DH, Jun SH, Lee CJ, Lee TH (September 2011). "A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear sequestration". Biochem. Biophys. Res. Commun. 412 (3): 454–9. doi:10.1016/j.bbrc.2011.07.117. PMID 21839727.
• Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA (December 2013). "Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells". Stem Cells. 31 (12): 2833–41. doi:10.1002/stem.1445. PMC 4617635. PMID 23765749.
• Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z, Li F, Chen H, Zhou Z, Zhang L, Ji H (March 2014). "VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex". Cell Res. 24 (3): 331–43. doi:10.1038/cr.2014.10. PMC 3945886. PMID 24458094.