Betatorquevirus
| Betatorquevirus | |
|---|---|
Virus classification  | |
| (unranked): | Virus |
| Realm: | Floreoviria |
| Kingdom: | Shotokuvirae |
| Phylum: | Commensaviricota |
| Class: | Cardeaviricetes |
| Order: | Sanitavirales |
| Family: | Anelloviridae |
| Genus: | Betatorquevirus |
Betatorquevirus is a genus of viruses in the family Anelloviridae, in group II in the Baltimore classification. The genus Betatorquevirus includes all "torque teno mini viruses" (TTMV), numbered from 1 to 38.
Taxonomy
[edit]The genus contains the following species:[1]
- Betatorquevirus homini1
- Betatorquevirus homini2
- Betatorquevirus homini3
- Betatorquevirus homini4
- Betatorquevirus homini5
- Betatorquevirus homini6
- Betatorquevirus homini7
- Betatorquevirus homini8
- Betatorquevirus homini9
- Betatorquevirus homini10
- Betatorquevirus homini11
- Betatorquevirus homini12
- Betatorquevirus homini13
- Betatorquevirus homini14
- Betatorquevirus homini15
- Betatorquevirus homini16
- Betatorquevirus homini17
- Betatorquevirus homini18
- Betatorquevirus homini19
- Betatorquevirus homini20
- Betatorquevirus homini21
- Betatorquevirus homini22
- Betatorquevirus homini23
- Betatorquevirus homini24
- Betatorquevirus homini25
- Betatorquevirus homini26
- Betatorquevirus homini27
- Betatorquevirus homini28
- Betatorquevirus homini29
- Betatorquevirus homini30
- Betatorquevirus homini31
- Betatorquevirus homini32
- Betatorquevirus homini33
- Betatorquevirus homini34
- Betatorquevirus homini35
- Betatorquevirus homini36
- Betatorquevirus homini37
- Betatorquevirus homini38
Initial discovery
[edit]The discovery of TTMV, like the original Torque Teno virus (TTV) isolate, was accidental. After TTV was isolated in 1997 from a Japanese patient, primers were created to study TTV in more detail. TTV-specific primers used in PCR of human plasma samples yielded sequences that partially matched that of TTV, but were noticeably shorter.[2][3] TTV was eventually understood to have a genome of 3.6–3.9 kb, while TTMV has a genome of 2.8–2.9 kb. Another TT-like virus later isolated in 2007, Torque teno midi virus or TTMDV, has a genome of 3.2 kb.[3]
Genome and capsid
[edit]TTMV shares similar morphologic features with the other human anelloviruses. The capsid has a T=1 icosahedral symmetry.[2] The virion does not have a lipid envelope and is thus "naked", making it an extremely simple virus. It is estimated that the virion is a little less than 30 nm in diameter.[2][3]
The genome is circular and made of single-stranded DNA of negative polarity. It is 2.86–2.91 kilobases long.[2] Anelloviruses are known for having 3 or 4 overlapping, nested open reading frames; TTMV has 3 ORF's that overlap.[2][4] ORF-2 and ORF-3 overlap with ORF-1 at opposite ends. For TTMV, ORF-1 is about 663 residues and ORF-2 is about 91 residues long.[2] There is a highly conserved 130-nt region just downstream of the TATA box.[3]
Phylogeny & spread
[edit]TTMV is highly divergent.[2][3] The first phylogenetic tree created from TTMV genomic sequences revealed a large cluster of strains; ORF-1 had divergences of over 42% at the nucleotide level and over 67% at the amino acid level.[2]
TTMV is also highly prevalent, like other human anelloviruses. Subsequent research after it was discovered has yielded the prevalence of TTMV DNA among blood donors to be 48%–72%.[3] It can likely infect a wide range of tissues, as it has been isolated from various body fluids and tissues, including saliva, feces, plasma/serum, PBMCs, bone marrow, spleen, pancreas, kidneys, nervous tissue, lymph nodes, semen, and cervical swabs.[2][3] Its exact transmission mechanism is unknown, but is thought to be possible by blood-borne, sexual, fecal-oral, and respiratory routes.[2]
Recent studies have shown that humans can have multiple infections of TT viruses.[3][4]
Clinical
[edit]Though TTVs are potentially associated with diseases and their pathogenicity has been debated since their discovery, TTMV is not currently known as an explicit cause of any human disease.[2] TTMV has been isolated from a number of parapneumonic empyema.[5] However, its clinical significance remains unclear.
References
[edit]- ↑ "Virus Taxonomy: 2024 Release". International Committee on Taxonomy of Viruses. Retrieved 25 March 2025.
- 1 2 3 4 5 6 7 8 9 10 11 Spandole, Sonia; Cimponeriu, Dănuţ; Berca, Lavinia Mariana; Mihăescu, Grigore (April 2015). "Human anelloviruses: an update of molecular, epidemiological and clinical aspects". Archives of Virology. 160 (4): 893–908. doi:10.1007/s00705-015-2363-9. PMID 25680568.
- 1 2 3 4 5 6 7 8 Okamoto, H (2009). "History of Discoveries and Pathogenicity of TT Viruses". TT Viruses. Current Topics in Microbiology and Immunology. Vol. 331. pp. 1–20. doi:10.1007/978-3-540-70972-5_1. ISBN 978-3-540-70971-8. PMID 19230554.
- 1 2 Zhang, Yu (May 6, 2016). "A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients". Scientific Reports. 6 (26739) 26739. Bibcode:2016NatSR...626739Z. doi:10.1038/srep26739. PMC 4879676. PMID 27221159.
- ↑ Galmès J, Li Y, Rajoharison A, Ren L, Dollet S, Richard N, Vernet G, Javouhey E, Wang J, Telles JN, Paranhos-Baccalà G (2012) Potential implication of new torque teno mini viruses in parapneumonic empyema in children. Eur Respir J
External links
[edit]- ICTV Virus Taxonomy 2009
- UniProt Taxonomy
- Anellovirus at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ICTVdb
- ViralZone: Betatorquevirus