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Thiazepine

From Wikipedia, the free encyclopedia
(Redirected from Thiazepines)
1,3-thiazepine
1,4-thiazepine
Diltiazem. 1,4-thiazepine is the seven membered ring in the middle.

Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound.[1] Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine.[1]

Benzothiazepines have a single benzene attached to the ring, while dibenzothiazepines have two. Diltiazem, a benzothiazepine, is a calcium channel blocker intermediate in properties between verapamil and the dihydropyridines. It is used to treat variant angina (Prinzmetal's angina), either naturally occurring or drug-induced and stable angina.

References

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  1. 1 2 "MeSH Browser". meshb.nlm.nih.gov. Retrieved 2022-11-24.
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