Tyrosyl-DNA phosphodiesterase 2

TDP2
Identifiers
Aliases	TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2
External IDs	OMIM: 605764; MGI: 1860486; GeneCards: TDP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5J3S, 5INO, 5J3P
Gene location (Human)
Chr.	Chromosome 6 (human)
End	24,666,930 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	25,026,136 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; mucosa of ileum; ; rectum; ; duodenum; ; mucosa of transverse colon; ; gonad; ; palpebral conjunctiva; ; kidney tubule; ; islet of Langerhans;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; primitive streak; ; tail of embryo; ; abdominal wall; ; atrioventricular valve; ; epiblast; ; ciliary body; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; single-stranded DNA binding; nuclease activity; protein binding; 5'-tyrosyl-DNA phosphodiesterase activity; manganese ion binding; transcription corepressor activity; magnesium ion binding; tyrosyl-RNA phosphodiesterase activity; hydrolase activity;
Cellular component	cytoplasm; PML body; nucleolus; nucleus; nucleoplasm; aggresome; nuclear body;
Biological process	cell surface receptor signaling pathway; double-strand break repair; DNA repair; nucleic acid phosphodiester bond hydrolysis; cellular response to DNA damage stimulus; negative regulation of nucleic acid-templated transcription; neuron development;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51567
	56196
	ENSG00000111802
	ENSMUSG00000035958
	O95551
	Q9JJX7
	NM_016614
	NM_019551
	NP_057698
	NP_062424
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosyl-DNA phosphodiesterase 2 is an enzyme that in humans is encoded by the gene TDP2 (previously TTRAP).^[5] The TDP2 protein functions as a DNA repair enzyme by removing covalent adducts from DNA.^[6] It functions in a similar role to the TDP1 enzyme, but it preferentially acts on 5'-phosphodiester bonds, while TDP1 is the faster and more efficient enzyme for 3'-phosphodiester bonds.^[6]

This protein is a member of a superfamily of divalent cation-dependent phosphodiesterases. It associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.^[5]

Interactions

TTRAP has been shown to interact with ETS1,^[7] TNFRSF1B^[8] and CD40.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111802 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035958 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: TTRAP TRAF and TNF receptor associated protein".
1 2 "Tyrosyl-DNA phosphodiesterase 2". uniprot.org. UniProt consortium. Retrieved 2026-09-10.
↑ Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R (May 2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene. 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. PMID 12743594. S2CID 35966215.
1 2 Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (June 2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.

Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R (2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene. 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. PMID 12743594. S2CID 35966215.
Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Luciano M, Lind PA, Duffy DL, Castles A, Wright MJ, Montgomery GW, Martin NG, Bates TC (2007). "A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability". Biol. Psychiatry. 62 (7): 811–7. doi:10.1016/j.biopsych.2007.03.007. PMID 17597587. S2CID 11334660.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111802 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035958 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: TTRAP TRAF and TNF receptor associated protein".

[uniprot-6] 1 2 "Tyrosyl-DNA phosphodiesterase 2". uniprot.org. UniProt consortium. Retrieved 2026-09-10.

[pmid12743594-7] Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R (May 2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene. 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. PMID 12743594. S2CID 35966215.

[pmid10764746-8] 1 2 Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (June 2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.

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Tyrosyl-DNA phosphodiesterase 2

Interactions

References

Further reading