Tripartite motif containing 34

TRIM34
Identifiers
Aliases	TRIM34, IFP1, RNF21, tripartite motif containing 34
External IDs	OMIM: 605684; HomoloGene: 136478; GeneCards: TRIM34; OMA:TRIM34 - orthologs
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EGP
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 5,619,764 bp End 5,644,398 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte lymph node blood spleen placenta granulocyte appendix right adrenal gland right adrenal cortex rectum n/a More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding metal ion binding molecular function Cellular component cytoplasm cytosol intracellular anatomical structure Biological process protein trimerization positive regulation of DNA-binding transcription factor activity defense response to virus interferon-gamma-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53840 n/a Ensembl ENSG00000258659 n/a UniProt Q9BYJ4 n/a RefSeq (mRNA) NM_130390 NM_001003827 NM_021616 NM_130389 n/a RefSeq (protein) NP_001003827 NP_067629 NP_569074 n/a Location (UCSC) Chr 11: 5.62 – 5.64 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Tripartite motif containing 34 is a protein that, in humans, is encoded by the TRIM34 gene.

Function

The protein encoded by this gene is a member of the tripartite motif family (TRIM). The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.