SCAF11

SCAF11
Identifiers
Aliases	SCAF11, CASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP, SR-related CTD associated factor 11
External IDs	OMIM: 603668; MGI: 1919443; GeneCards: SCAF11
Gene location (Human)
Chr.	Chromosome 12 (human)
End	45,992,120 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	96,358,724 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; epithelium of colon; ; tendon of biceps brachii; ; Achilles tendon; ; lower lobe of lung; ; jejunal mucosa; ; pylorus; ; tonsil; ; oral cavity; ; sural nerve;
	Top expressed in
	tail of embryo; ; genital tubercle; ; mandibular prominence; ; maxillary prominence; ; epithelium of stomach; ; ankle; ; skin of external ear; ; abdominal wall; ; tibiofemoral joint; ; cumulus cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; RNA binding;
Cellular component	nucleolus; nucleus; nucleoplasm; nuclear body;
Biological process	RNA splicing, via transesterification reactions; mRNA processing; spliceosomal complex assembly; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9169
	72193
	ENSG00000139218
	ENSMUSG00000033228
	Q99590
	n/a
	NM_004719
	NM_028148
	NP_004710
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

SR-related CTD associated factor 11 is a protein that in humans is encoded by the SCAF11 gene (previously SFRS2IP).^[5]^[6]^[7] This protein is involved in regulating the assembly of the spliceosome.^[7]

Interactions

SCAF11 has been shown to interact with U2AF2.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139218 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033228 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tanner S, Stagljar I, Georgiev O, Schaffner W, Bourquin JP (Aug 1997). "A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain". Biol Chem. 378 (6): 565–71. doi:10.1515/bchm.1997.378.6.565. PMID 9224939.
1 2 Zhang WJ, Wu JY (Feb 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol Cell Biol. 18 (2): 676–84. doi:10.1128/mcb.18.2.676. PMC 108778. PMID 9447963.
1 2 "Entrez Gene: SFRS2IP splicing factor, arginine/serine-rich 2, interacting protein".

Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-14.
van de Craen M, de Jonghe C, van den Brande I, et al. (1999). "Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases" (PDF). FEBS Lett. 445 (1): 149–54. doi:10.1016/S0014-5793(99)00108-8. hdl:10067/238040151162165141. PMID 10069390. S2CID 31218178.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000139218 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033228 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9224939-5] Tanner S, Stagljar I, Georgiev O, Schaffner W, Bourquin JP (Aug 1997). "A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain". Biol Chem. 378 (6): 565–71. doi:10.1515/bchm.1997.378.6.565. PMID 9224939.

[pmid9447963-6] 1 2 Zhang WJ, Wu JY (Feb 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol Cell Biol. 18 (2): 676–84. doi:10.1128/mcb.18.2.676. PMC 108778. PMID 9447963.

[entrez-7] 1 2 "Entrez Gene: SFRS2IP splicing factor, arginine/serine-rich 2, interacting protein".

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SCAF11

Interactions

References

Further reading