CTDSP1

CTDSP1
Identifiers
Aliases	CTDSP1, NIF3, NLI-IF, NLIIF, SCP1, CTD small phosphatase 1
External IDs	OMIM: 605323; MGI: 2654470; HomoloGene: 100834; GeneCards: CTDSP1; OMA:CTDSP1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T9Z, 1TA0, 2GHQ, 2GHT, 3L0B, 3L0C, 3L0Y, 3PGL, 4YGY, 4YH1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,405,941 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,436,444 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right coronary artery; ; gastric mucosa; ; body of stomach; ; Descending thoracic aorta; ; apex of heart; ; left uterine tube; ; right ovary; ; canal of the cervix; ; popliteal artery;
	Top expressed in
	granulocyte; ; urinary bladder; ; adrenal gland; ; white adipose tissue; ; muscle tissue; ; muscle of thigh; ; human kidney; ; lip; ; skeletal muscle tissue; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatase activity; RNA polymerase II CTD heptapeptide repeat phosphatase activity; protein binding; phosphoprotein phosphatase activity; hydrolase activity; metal ion binding;
Cellular component	extracellular exosome; nucleus; nucleoplasm;
Biological process	regulation of transcription by RNA polymerase II; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of protein phosphorylation; negative regulation of neurogenesis; protein dephosphorylation; negative regulation of neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	58190
	227292
	ENSG00000144579
	ENSMUSG00000026176
	Q9GZU7
	P58466
	NM_001206878; NM_001206879; NM_021198; NM_182642
	NM_153088
	NP_001193807; NP_067021; NP_872580
	NP_694728
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.^[5]^[6]^[7]

Interactions

CTDSP1 has been shown to interact with SNAI1.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144579 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026176 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". Journal of Human Genetics. 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.
↑ Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
↑ "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
↑ Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.

External links

Human CTDSP1 genome location and CTDSP1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000144579 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026176 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11950066-5] Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". Journal of Human Genetics. 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.

[pmid12721286-6] Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.

[entrez-7] "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".

[pmid19004823-8] Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.

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CTDSP1

Interactions

References

Further reading

External links