Polysaccharide-K
Polysaccharide-K (Krestin, PSK) is a protein-bound polysaccharide isolated from the mycelium[1][2] of Trametes versicolor.
Although PSK is approved in Japan as an adjuvant therapy in cancer treatment,[3] it is not approved in the United States for treatment of cancer or any clinical condition.[4]
Research
[edit]There is little evidence that turkey tail mushroom extracts or PSK are useful for treating cancer or any medical condition.[4]
Polysaccharide-K, an extract of T. versicolor, is approved in Japan as an adjuvant therapy in cancer treatment.[3]
Chemistry
[edit]PSK is a protein polysaccharide consisting of a beta-glucan β-1,4 main chain with β-1,3 and β-1,6 side chains. The approximate molecular weight of PSK is 100,000 Da, and the protein component is reported at the β-1,6 side chain.[5] PSK is isolated from the "CM-101" strain of Trametes versicolor. The analogous compound PSP, is derived from the "COV-1" strain of Trametes versicolor.[6]
See also
[edit]
References
[edit]- ↑ Yang, Dandan; Zhou, Zijing; Zhang, Lijuan (2019). Progress in Molecular Biology and Translational Science. Vol. 163. Chapter Eight - An overview of fungal glycan-based therapeutics: Academic Press. pp. 135–163. doi:10.1016/bs.pmbts.2019.02.001. ISBN 9780128177402. PMID 31030746. Retrieved 24 January 2023.
- ↑ Habtemariam, Solomon (2020). "Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy". Biomedicines. 8 (5): 135. doi:10.3390/biomedicines8050135. PMC 7277906. PMID 32466253.
- 1 2 "Turkey Tail Uses, Benefits & Dosage". Drugs.com. Retrieved 2025-06-20.
- 1 2 "Medicinal Mushrooms (PDQ)". Physician Data Query (PDQ), US National Cancer Institute. 2 March 2017. Retrieved 20 June 2025.
- ↑ Kobayashi H, Matsunaga K, Oguchi Y (1995). "Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview". Cancer Epidemiology, Biomarkers & Prevention. 4 (3): 275–81. PMID 7606203.
- ↑ Fisher M, Yang LX (2002). "Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy". Anticancer Research. 22 (3): 1737–54. PMID 12168863.