Neuropilin 2

NRP2
Identifiers
Aliases	NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2
External IDs	OMIM: 602070; MGI: 1100492; GeneCards: NRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QQJ, 2QQK, 2QQL, 2QQO, 4QDQ, 4QDR, 4QDS, 5DN2
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.3 Start 205,681,990 bp End 205,798,133 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C2 Start 62,742,444 bp End 62,857,854 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa epithelium of colon muscle layer of sigmoid colon cartilage tissue body of uterus Achilles tendon smooth muscle tissue gallbladder left ovary Top expressed in calvaria body of femur habenula epithelium of bronchiole stroma of bone marrow dermis genital tubercle olfactory tubercle hair follicle tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor-activated receptor activity heparin binding semaphorin receptor activity growth factor binding metal ion binding cytokine binding protein binding identical protein binding signaling receptor activity Cellular component integral component of membrane membrane plasma membrane semaphorin receptor complex extracellular region axon glutamatergic synapse integral component of postsynaptic membrane Biological process sympathetic ganglion development cell differentiation semaphorin-plexin signaling pathway involved in neuron projection guidance positive regulation of endothelial cell proliferation vascular endothelial growth factor signaling pathway nervous system development axon guidance positive regulation of endothelial cell migration multicellular organism development sympathetic neuron projection guidance vascular endothelial growth factor receptor signaling pathway cell adhesion angiogenesis nerve development sympathetic neuron projection extension axon extension involved in axon guidance outflow tract septum morphogenesis neural crest cell migration neuron migration development of the heart facial nerve structural organization vestibulocochlear nerve structural organization gonadotrophin-releasing hormone neuronal migration to the hypothalamus ventral trunk neural crest cell migration negative chemotaxis trigeminal ganglion development sensory neuron axon guidance neural crest cell migration involved in autonomic nervous system development facioacoustic ganglion development dorsal root ganglion morphogenesis cellular response to leukemia inhibitory factor regulation of postsynapse organization viral process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8828 18187 Ensembl ENSG00000118257 ENSMUSG00000025969 UniProt O60462 O35375 RefSeq (mRNA) NM_003872 NM_018534 NM_201264 NM_201266 NM_201267 NM_201279 NM_001077403 NM_001077404 NM_001077405 NM_001077406 NM_001077407 NM_010939 RefSeq (protein) NP_003863 NP_061004 NP_957716 NP_957718 NP_957719 NP_958436 NP_001070871 NP_001070872 NP_001070873 NP_001070874 NP_001070875 NP_035069 Location (UCSC) Chr 2: 205.68 – 205.8 Mb Chr 1: 62.74 – 62.86 Mb PubMed search
Wikidata
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Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.

This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (January 1999). "Vascular endothelial growth factor (VEGF) and its receptors". FASEB Journal. 13 (1): 9–22. doi:10.1096/fasebj.13.1.9. PMID 9872925. S2CID 1151216.
• Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD (August 1997). "Neuropilin is a semaphorin III receptor". Cell. 90 (4): 753–62. doi:10.1016/S0092-8674(00)80535-8. PMID 9288754. S2CID 17268123.
• Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (November 1998). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi:10.1016/S0896-6273(00)80625-X. PMID 9856463. S2CID 18445456.
• Chen H, He Z, Bagri A, Tessier-Lavigne M (December 1998). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron. 21 (6): 1283–90. doi:10.1016/S0896-6273(00)80648-0. PMID 9883722.
• Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (October 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nature Neuroscience. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546. S2CID 38320889.
• Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (May 1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics. 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.
• Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, et al. (October 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
• Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (June 2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". The Journal of Biological Chemistry. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.
• Handa A, Tokunaga T, Tsuchida T, Lee YH, Kijima H, Yamazaki H, et al. (August 2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma". International Journal of Oncology. 17 (2): 291–5. doi:10.3892/ijo.17.2.291. PMID 10891538.
• Rossignol M, Gagnon ML, Klagsbrun M (December 2000). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics. 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.
• Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (June 2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes". The Journal of Biological Chemistry. 276 (22): 18688–94. doi:10.1074/jbc.M006909200. PMID 11278319.
• Cohen T, Gluzman-Poltorak Z, Brodzky A, Meytal V, Sabo E, Misselevich I, et al. (June 2001). "Neuroendocrine cells along the digestive tract express neuropilin-2". Biochemical and Biophysical Research Communications. 284 (2): 395–403. doi:10.1006/bbrc.2001.4958. PMID 11394892.
• Herzog Y, Kalcheim C, Kahane N, Reshef R, Neufeld G (November 2001). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins". Mechanisms of Development. 109 (1): 115–9. doi:10.1016/S0925-4773(01)00518-4. PMID 11677062. S2CID 18341197.
• Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A, Honda Y (January 2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 383–8. Bibcode:2002PNAS...99..383O. doi:10.1073/pnas.012074399. PMC 117569. PMID 11756651.
• Fakhari M, Pullirsch D, Abraham D, Paya K, Hofbauer R, Holzfeind P, et al. (January 2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer. 94 (1): 258–63. doi:10.1002/cncr.10177. PMID 11815985. S2CID 45773136.
• Cohen T, Herzog Y, Brodzky A, Greenson JK, Eldar S, Gluzman-Poltorak Z, et al. (September 2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours". The Journal of Pathology. 198 (1): 77–82. doi:10.1002/path.1179. PMID 12210066. S2CID 24579823.
• Kawakami T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Abe Y, et al. (November 2002). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma". Cancer. 95 (10): 2196–201. doi:10.1002/cncr.10936. PMID 12412174. S2CID 28744286.