Iodocholesterol

Iodocholesterol
Clinical data
Other names	Iodocholesterol; 19-Iodocholesterol; Iodocholesterol (131I); 19-Iodocholest-5-en-3β-ol
ATC code	V09XA02 (WHO) (131I);
Identifiers
	IUPAC name (3S,8S,9S,10S,13R,14S,17R)-10-(iodomethyl)-13-methyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;
CAS Number	37414-03-2;
PubChem CID	3032874;
ChemSpider	20086815 ;
UNII	4A4E6EXB6U;
CompTox Dashboard (EPA)	DTXSID80190857 ;
ECHA InfoCard	100.048.618
Chemical and physical data
Formula	C27H45IO
Molar mass	512.560 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)CCC[C@@H](C)[C@H]3CC[C@H]2[C@@H]4C\C=C1\C[C@@H](O)CC[C@]1(CI)[C@H]4CC[C@@]23C;
	InChI InChI=1S/C27H45IO/c1-18(2)6-5-7-19(3)23-10-11-24-22-9-8-20-16-21(29)12-15-27(20,17-28)25(22)13-14-26(23,24)4/h8,18-19,21-25,29H,5-7,9-17H2,1-4H3/t19-,21+,22+,23-,24+,25+,26-,27-/m1/s1 ; Key:FIOAEFCJGZJUPW-FTLVODPJSA-N ;
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Iodocholesterol, or 19-iodocholesterol, also as iodocholesterol (¹³¹I) (INN) and NP-59, is a derivative of cholesterol with an iodine atom in the C19 position and a radiopharmaceutical.^[1]^[2] When the iodine atom is a radioactive isotope (iodine-125 or iodine-131), it is used as an adrenal cortex radiotracer in the diagnosis of patients suspected of having Cushing's syndrome, hyperaldosteronism,^[3] pheochromocytoma, and adrenal remnants following total adrenalectomy.^[1]^[2]

References

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