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Oxford Nanopore Technologies

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Oxford Nanopore Technologies plc
TypePublic limited company
ISINGB00BP6S8Z30
IndustryNanopore sequencing
Founded2005; 21 years ago (2005)
Founders
Headquarters
Oxford Science Park, Oxford
,
United Kingdom
Key people
  • Duncan Tatton-Brown (Chair)
  • Francis Van Parys (CEO)
RevenueIncrease £223.9 million (2025)[1]
Decrease £(155.3) million (2025)[1]
Increase £(145.2) million (2025)[1]
Websitenanoporetech.com

Oxford Nanopore Technologies plc is a UK-based company which develops and sells nanopore-based molecular sensing technology for the real-time analysis of DNA and RNA.[2][3][4] Its platform includes sequencing devices, consumables and software used across research, applied and clinical markets.[5][6][7] It is listed on the London Stock Exchange and is a constituent of the FTSE 250 Index.[8]

History

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The company was founded in 2005 as a spin-out from the University of Oxford by Hagan Bayley,[9] Gordon Sanghera, and Spike Willcocks, with seed funding from the IP Group.[10] The company made an initial public offering on the London Stock Exchange on 30 September 2021, under the ticker ONT.[11]

In March 2016 the company announced a chemistry upgrade to its nanopore sequencing product 'R9', using a protein nanopore in collaboration with the laboratory of Han Remaut (VIB/Vrije Universiteit Brussel).[12] The company stated in a webcast that R9 is designed to improve error rates and yield.[13]

NASA astronaut Kate Rubins with a MinION sequencer on the ISS in August 2016.

In December 2025, the company announced that Francis Van Parys would succeed Gordon Sanghera as CEO.[14] Prior to joining Oxford Nanopore, he was President and CEO of Radiometer and held senior leadership roles at Cytiva and GE Healthcare.[14]

Products

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Top view of a closed Oxford Nanopore Technologies MinION sequencer showing how it is small enough to be held in one hand

The main products of Oxford Nanopore are:

  • MinION:[15][16][17] this harmonica-sized portable protein nanopore sequencing USB device has been commercially available since May 2015.[18]
  • GridION: this desktop device has been commercially available since March 2017.[19] The device processes up to five MinION flow cells and enables generation of up to 100 Gb of data per run.[20]
  • PromethION: a desktop device for sequencing of native DNA or RNA samples.[21] The device contains channels for 144,000 nanopores (in comparison to MinION’s 512)[22] and delivers up to 290 Gb of data per flow cell.[23]
  • PromethION 24: this device is a nanopore sequencing platform released in 2019 for DNA and RNA sequencing projects[24]. It 24 flow cells which can be run independently.[25]
  • EPI2ME: a procut for customers with limited computational experience to process data without high-performance computing resources and programming expertise.[26][27]

These products are intended to be used for the analysis of DNA, RNA, proteins and small molecules with a range of applications in personalized medicine, Agricultural science and scientific research.[28]

References

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  1. 1 2 3 "Annual Results for year ended 31 December 2025". Oxford Nanopore Technologies. Retrieved 2 March 2026.
  2. ↑ Eisenstein, M. (2012). "Oxford Nanopore announcement sets sequencing sector abuzz". Nature Biotechnology. 30 (4): 295–6. Bibcode:2012NatBi..30..295E. doi:10.1038/nbt0412-295. PMID 22491260. S2CID 205267199.
  3. ↑ Engineer, The (8 July 2026). "Gene sequencing pioneer Oxford Nanopore Technologies wins 2026 MacRobert Award". The Engineer. Retrieved 24 July 2026.
  4. ↑ Eisenstein, Michael (10 April 2012). "Oxford Nanopore announcement sets sequencing sector abuzz". Nature Biotechnology. 30 (4): 295–296. doi:10.1038/nbt0412-295. ISSN 1087-0156.
  5. ↑ Pugh, Jonathan (2023), Arakawa, Kazuharu (ed.), "The Current State of Nanopore Sequencing", Nanopore Sequencing, vol. 2632, New York, NY: Springer US, pp. 3–14, doi:10.1007/978-1-0716-2996-3_1, ISBN 978-1-0716-2995-6, retrieved 18 August 2026{{citation}}: CS1 maint: work parameter with ISBN (link)
  6. ↑ Si, Hua-Qi; Wang, Peng; Long, Fei; Zhong, Wei; Meng, Yuan-Dong; Rong, Yuan; Meng, Xiang-Yu; Wang, Fu-Bing (29 November 2024). "Cancer liquid biopsies by Oxford Nanopore Technologies sequencing of cell-free DNA: from basic research to clinical applications". Molecular Cancer. 23 (1). doi:10.1186/s12943-024-02178-6. ISSN 1476-4598. PMC 11605934. PMID 39614371.
  7. ↑ Loman, N. J.; Quinlan, A. R. (2014). "Poretools: A toolkit for analyzing nanopore sequence data". Bioinformatics. 30 (23): 3399–401. doi:10.1093/bioinformatics/btu555. PMC 4296151. PMID 25143291.
  8. ↑ "FTSE UK Index Series Quarterly Review December 2024". FTSE Russell. 4 December 2024. Retrieved 20 December 2024.
  9. ↑ "BAYLEY, Prof. (John) Hagan (Pryce)". Who's Who. Vol. 2015 (online edition via Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  10. ↑ "DNA sequencing: The hole story". The Economist. London. 16 October 2008. Retrieved 19 October 2014.
  11. ↑ "London Stock Exchange welcomes Oxford Nanopore Technologies plc to the Main Market". 11 October 2021.
  12. ↑ "VIB announces collaboration with Oxford Nanopore Technologies on new DNA sequencing nanopore". Retrieved 9 May 2016.
  13. ↑ "No thanks, I've already got one". YouTube. 8 March 2016. Retrieved 9 May 2016.
  14. 1 2 "Appointment of Francis Van Parys as Chief Executive Officer". Business Wire. 8 December 2025. Retrieved 24 July 2026.{{cite web}}: CS1 maint: url-status (link)
  15. ↑ Mikheyev, A. S.; Tin, M. M. Y. (2014). "A first look at the Oxford Nanopore MinION sequencer". Molecular Ecology Resources. 14 (6): 1097–102. Bibcode:2014MolER..14.1097M. doi:10.1111/1755-0998.12324. PMID 25187008. S2CID 3674911.
  16. ↑ Check Hayden, E. (2014). "Data from pocket-sized genome sequencer unveiled". Nature. doi:10.1038/nature.2014.14724.
  17. ↑ Check Hayden, E. (2015). "Pint-sized DNA sequencer impresses first users". Nature. 521 (7550): 15–6. Bibcode:2015Natur.521...15C. doi:10.1038/521015a. PMID 25951262.
  18. ↑ "IP Group PLC – Portfolio company Oxford Nanopore announces £70m fundraising – IP Group PLC". Archived from the original on 21 November 2015. Retrieved 20 November 2015.
  19. ↑ "Oxford Nanopore Launches GridIon X5 Nanopore Sequencer, Details Product Improvements". GenomeWeb. Retrieved 6 July 2017.
  20. ↑ "GridION X5". nanoporetech.com. Retrieved 6 July 2017.
  21. ↑ Faucher, Lisa (11 March 2022). "PromethION: Flexible, large-scale, direct DNA and RNA sequencing". BioTechniques. Retrieved 24 July 2026.
  22. ↑ "Specifications - Community - Oxford Nanopore Technologies". Archived from the original on 1 June 2016. Retrieved 20 November 2015.
  23. ↑ "Oxford Nanopore Technologies: Oxford Nanopore launches PromethION 2 Integrated into open early access". FinanzNachrichten.de (in German). Retrieved 24 July 2026.
  24. ↑ "Oxford Nanopore PromethION 24/48". genohub.com. Retrieved 18 August 2026.
  25. ↑ "PromethION 24: sequencing to the power of 24". Oxford Nanopore Technologies. Retrieved 18 August 2026.
  26. ↑ Quiñones-Sanchez, Carlos L.; Bilbao-Del Valle, Jan L.; Urdaneta-Colon, Miguel A.; Santiago-Rodriguez, Tasha M.; Rodriguez-Fernandez, Imilce A. (15 November 2025), Optimizing Tissue Lysis and DNA Extraction Protocols to Enhance Bacterial Diversity Profiling in the Drosophila melanogaster Gut Microbiome, doi:10.1101/2025.11.15.688634, PMC 12642230, PMID 41292709, retrieved 18 August 2026
  27. ↑ Oxford Nanopore Technologies (5 June 2026). EPI2ME evolution – latest developments and the road ahead. Retrieved 25 July 2026 – via YouTube.
  28. ↑ Check Hayden, Erika (2012). "Nanopore genome sequencer makes its debut". Nature. doi:10.1038/nature.2012.10051. ISSN 1744-7933.
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