Myosin regulatory light chain 12B

MYL12B
Identifiers
Aliases	MYL12B, MLC-B, MRLC2, myosin light chain 12B
External IDs	OMIM: 609211; MGI: 1914518; GeneCards: MYL12B
Gene location (Human)
Chr.	Chromosome 18 (human)
End	3,278,461 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	71,309,873 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; pancreatic ductal cell; ; mucosa of colon; ; mucosa of sigmoid colon; ; right lung; ; jejunal mucosa; ; renal medulla; ; mucosa of transverse colon; ; islet of Langerhans; ; right adrenal gland;
	Top expressed in
	endothelial cell of lymphatic vessel; ; right lung lobe; ; external carotid artery; ; internal carotid artery; ; left lung lobe; ; vas deferens; ; calvaria; ; myocardium of ventricle; ; soleus muscle; ; decidua;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; myosin heavy chain binding; protein binding; metal ion binding;
Cellular component	myosin II complex; cytosol; apical part of cell; Z discdkac; extracellular exosome; brush border; myosin complex; stress fiber; cell cortex region;
Biological process	muscle contraction; regulation of cell shape;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	103910
	67268
	ENSG00000118680
	ENSMUSG00000024048
	O14950
	n/a
	NM_033546; NM_001144944; NM_001144945; NM_001144946
	NM_026064; NM_001357820
NP_001138416; NP_001138417; NP_291024; NP_001289976; NP_001289977;
	NP_001289978; NP_006462
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin regulatory light chain 12B is a protein that in humans is encoded by the MYL12B gene.^[5] The gene is also known as MLC-B and MRLC2.^[5] The activity of nonmuscle myosin II is regulated by phosphorylation of a regulatory light chain, such as MYL12B. This phosphorylation results in higher ATPase activity and the assembly of myosin II filaments.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000118680 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024048 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Myosin, light chain 12B, regulatory". Retrieved 2011-12-05.
↑ Iwasaki T, Murata-Hori M, Ishitobi S, Hosoya H (December 2001). "Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells". Cell Structure and Function. 26 (6): 677–683. doi:10.1247/csf.26.677. PMID 11942626.

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Myosin regulatory light chain 12B

See also

References

Further reading