Mitochondrial ribosomal protein S6

MRPS6
Identifiers
Aliases	MRPS6, C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6
External IDs	OMIM: 611973; MGI: 2153111; HomoloGene: 41871; GeneCards: MRPS6; OMA:MRPS6 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.11 Start 34,073,224 bp End 34,143,034 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C4 Start 91,855,158 bp End 91,909,115 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla left lobe of thyroid gland decidua gonad human kidney right lobe of thyroid gland tibial arteries right adrenal cortex right coronary artery tibial nerve Top expressed in vestibular membrane of cochlear duct Epithelium of choroid plexus vestibular sensory epithelium retinal pigment epithelium epithelium of lens endothelial cell of lymphatic vessel ciliary body right kidney medullary collecting duct sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome rRNA binding protein binding small ribosomal subunit rRNA binding Cellular component small ribosomal subunit mitochondrial inner membrane ribosome mitochondrial small ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64968 121022 Ensembl ENSG00000243927 ENSMUSG00000039680 UniProt P82932 P58064 RefSeq (mRNA) NM_032476 NM_080456 RefSeq (protein) NP_115865 NP_536704 Location (UCSC) Chr 21: 34.07 – 34.14 Mb Chr 16: 91.86 – 91.91 Mb PubMed search
Wikidata
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28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.

Further reading

• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. CiteSeerX 10.1.1.501.8919. doi:10.1074/jbc.M100727200. PMID 11279123.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Reymond A, Camargo AA, Deutsch S, et al. (2002). "Nineteen additional unpredicted transcripts from human chromosome 21". Genomics. 79 (6): 824–32. doi:10.1006/geno.2002.6781. PMID 12036297.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• Overview of all the structural information available in the PDB for UniProt: P82932 (28S ribosomal protein S6, mitochondrial) at the PDBe-KB.