Mitochondrial ribosomal protein L24

MRPL24
Identifiers
Aliases	MRPL24, L24mt, MRP-L18, MRP-L24, mitochondrial ribosomal protein L24
External IDs	OMIM: 611836; MGI: 1914957; GeneCards: MRPL24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.1 Start 156,737,303 bp End 156,741,590 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 87,826,813 bp End 87,830,979 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas apex of heart muscle of thigh right adrenal gland left adrenal cortex islet of Langerhans right adrenal cortex right lobe of liver gastrocnemius muscle mucosa of transverse colon Top expressed in endocardial cushion seminal vesicula spermatocyte interventricular septum efferent ductule cumulus cell cardiac muscle tissue of left ventricle Gonadal ridge medial ganglionic eminence dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 79590 67707 Ensembl ENSG00000143314 ENSMUSG00000019710 UniProt Q96A35 Q9CQ06 RefSeq (mRNA) NM_024540 NM_145729 NM_026591 RefSeq (protein) NP_078816 NP_663781 NP_080867 Location (UCSC) Chr 1: 156.74 – 156.74 Mb Chr 3: 87.83 – 87.83 Mb PubMed search
Wikidata
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39S ribosomal protein L24, mitochondrial is a protein that in humans is encoded by the MRPL24 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its Escherichia coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• O'Brien TW, Liu J, Sylvester JE, et al. (2000). "Mammalian mitochondrial ribosomal proteins (4). Amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 275 (24): 18153–9. doi:10.1074/jbc.M909762199. PMID 10751423.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.