Galectin-related protein

LGALSL
Identifiers
Aliases	LGALSL, GRP, HSPC159, galectin like
External IDs	OMIM: 617902; MGI: 1916114; GeneCards: LGALSL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JJ6, 3B9C
Gene location (Human) Chr. Chromosome 2 (human) Band 2p14 Start 64,453,969 bp End 64,461,381 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A3.1|11 13.53 cM Start 20,773,576 bp End 20,781,056 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip gums gingival epithelium vulva Skeletal muscle tissue of rectus abdominis skin of abdomen human penis oral cavity Skeletal muscle tissue of biceps brachii Top expressed in retinal pigment epithelium hair follicle skin of external ear intercostal muscle barrel cortex skin of abdomen pineal gland vastus lateralis muscle lobe of cerebellum triceps brachii muscle More reference expression data BioGPS More reference expression data
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 29094 216551 Ensembl ENSG00000119862 ENSMUSG00000042363 UniProt Q3ZCW2 Q8VED9 RefSeq (mRNA) NM_014181 NM_173752 RefSeq (protein) NP_054900 NP_776113 Location (UCSC) Chr 2: 64.45 – 64.46 Mb Chr 11: 20.77 – 20.78 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Galectin-related protein is a protein which in humans is encoded by the gene LGALSL (previously HSPC159 or GRP). It is related to other galectin proteins, but unlike others, it does not bind to lactose, and may not bind to any carbohydrates due to changes in resides that are important for carbohydrate binding.

Further reading

• Ahmed H, Vasta GR (2007). "Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a functional carbohydrate-binding galectin". Biochem. Biophys. Res. Commun. 371 (3): 350–5. doi:10.1016/j.bbrc.2008.04.078. PMC 2766801. PMID 18448074.
• Zhou D, Sun J, Zhao W, et al. (2006). "Expression, purification, crystallization and preliminary X-ray characterization of the GRP carbohydrate-recognition domain from Homo sapiens". Acta Crystallographica Section F. 62 (Pt 5): 474–6. doi:10.1107/S1744309106012875. PMC 2219983. PMID 16682780.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.