3-hydroxyisobutyryl-CoA hydrolase
(Redirected from HIBCH)
| 3-hydroxyisobutyryl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 3-hydroxyisobutyryl-CoA hydrolase monomer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 3.1.2.4 | ||||||||
| CAS no. | 9025-88-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) catalyzes the reaction
- 3-hydroxy-2-methylpropanoyl-CoA + H2O CoA + 3-hydroxy-2-methylpropanoate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, β-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.[1]
References
[edit]- ↑ "OMIM Entry - * 610690 - 3-HYDROXYISOBUTYRYL-CoA HYDROLASE; HIBCH". www.omim.org. Retrieved 2017-11-20.
- Rendina G, Coon MJ (March 1957). "Enzymatic hydrolysis of the coenzyme A thiol esters of β-hydroxypropionic and β-hydroxyisobutyric acids". The Journal of Biological Chemistry. 225 (1): 523–34. doi:10.1016/S0021-9258(18)64949-X. PMID 13457352.
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