Far upstream element–binding protein 1

FUBP1
Identifiers
Aliases	FUBP1, FBP, FUBP, hDH V, far upstream element binding protein 1
External IDs	OMIM: 603444; MGI: 1196294; GeneCards: FUBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J4W, 2KXH, 4LIJ
Gene location (Human)
Chr.	Chromosome 1 (human)
End	77,979,110 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	151,942,463 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; left ovary; ; right uterine tube; ; right ovary; ; body of uterus; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; canal of the cervix;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; maxillary prominence; ; mandibular prominence; ; epiblast; ; somite; ; abdominal wall; ; ganglionic eminence; ; Rostral migratory stream;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; single-stranded DNA binding; DNA-binding transcription factor activity; DNA binding; RNA binding;
Cellular component	nucleus; nucleoplasm;
Biological process	positive regulation of gene expression; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8880
	51886
	ENSG00000162613
	ENSMUSG00000028034
	Q96AE4
	Q91WJ8
	NM_001303433; NM_003902; NM_001376055; NM_001376056; NM_001376057
NM_057172; NM_001355366; NM_001355367; NM_001355368; NM_001355369;
	NM_001355370; NM_001355371; NM_001355372; NM_001355373; NM_001355374
	NP_001290362; NP_003893; NP_001362984; NP_001362985; NP_001362986
NP_476513; NP_001342295; NP_001342296; NP_001342297; NP_001342298;
	NP_001342299; NP_001342300; NP_001342301; NP_001342302; NP_001342303
	Wikidata
View/Edit Human	View/Edit Mouse

Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.^[5]^[6]

This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.^[6]

Interactions

Far upstream element-binding protein 1 has been shown to interact with MAPK14^[7] and SMN1.^[8]

Clinical significance

FUBP1 gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour.^[9] CIC gene is also lost in the 1p/19q codeletion mutation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162613 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028034 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (April 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259.
1 2 "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".
↑ Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (July 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3). United States: 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782. S2CID 41006480.
↑ Williams, B Y; Hamilton S L; Sarkar H K (March 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2). NETHERLANDS: 207–10. Bibcode:2000FEBSL.470..207W. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235. S2CID 28330997.
↑ Weller, Michael (8 December 2020). "EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood". Nature Reviews. Clinical Oncology. 18 (3): 170–186. doi:10.1038/s41571-020-00447-z. PMC 7904519. PMID 33293629.

Williams BY, Hamilton SL, Sarkar HK (2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2): 207–10. Bibcode:2000FEBSL.470..207W. doi:10.1016/S0014-5793(00)01320-X. PMID 10734235. S2CID 28330997.
Liu J, He L, Collins I, et al. (2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Mol. Cell. 5 (2): 331–41. doi:10.1016/S1097-2765(00)80428-1. PMID 10882074.
Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
He L, Weber A, Levens D (2000). "Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor". Nucleic Acids Res. 28 (22): 4558–65. doi:10.1093/nar/28.22.4558. PMC 113884. PMID 11071946.
Vindigni A, Ochem A, Triolo G, Falaschi A (2001). "Identification of human DNA helicase V with the far upstream element-binding protein". Nucleic Acids Res. 29 (5): 1061–7. doi:10.1093/nar/29.5.1061. PMC 29729. PMID 11222755.
Liu J, Akoulitchev S, Weber A, et al. (2001). "Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum". Cell. 104 (3): 353–63. doi:10.1016/S0092-8674(01)00223-9. PMID 11239393.
Braddock DT, Louis JM, Baber JL, et al. (2002). "Structure and dynamics of KH domains from FBP bound to single-stranded DNA". Nature. 415 (6875): 1051–6. Bibcode:2002Natur.415.1051B. doi:10.1038/4151051a. PMID 11875576. S2CID 4401103.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782. S2CID 41006480.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kouzine F, Liu J, Sanford S, et al. (2004). "The dynamic response of upstream DNA to transcription-generated torsional stress". Nat. Struct. Mol. Biol. 11 (11): 1092–100. doi:10.1038/nsmb848. PMID 15502847. S2CID 28956216.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
Liu J, Kouzine F, Nie Z, et al. (2006). "The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression". EMBO J. 25 (10): 2119–30. doi:10.1038/sj.emboj.7601101. PMC 1462968. PMID 16628215.
Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi:10.1074/jbc.C600041200. PMID 16672220.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162613 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028034 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8125259-5] Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (April 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259.

[entrez-6] 1 2 "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".

[pmid12819782-7] Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (July 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3). United States: 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782. S2CID 41006480.

[pmid10734235-8] Williams, B Y; Hamilton S L; Sarkar H K (March 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2). NETHERLANDS: 207–10. Bibcode:2000FEBSL.470..207W. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235. S2CID 28330997.

[9] Weller, Michael (8 December 2020). "EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood". Nature Reviews. Clinical Oncology. 18 (3): 170–186. doi:10.1038/s41571-020-00447-z. PMC 7904519. PMID 33293629.

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Far upstream element–binding protein 1

Interactions

Clinical significance

References

Further reading