Dexchlorpheniramine
(Redirected from Dexchlorphenamine)
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| Trade names | Chlor-trimeton, Polaramine |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682543 |
| Routes of administration | Oral, Intravenous |
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| Elimination half-life | 21 to 27 hours |
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| ECHA InfoCard | 100.042.779 |
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| Formula | C16H19ClN2 |
| Molar mass | 274.79 g·mol−1 |
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Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.[1][2] It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
It came into medical use in 1959 and was patented in 1962.[3]
Pharmacology
[edit]Dexchlorpheniramine is an antihistamine, or an antagonist of the histamine H1 receptor. A study found that dexchlorpheniramine had a Ki value of 20 to 30 μM for the muscarinic acetylcholine receptors using rat brain tissue.[4]
References
[edit]- ↑ Theunissen EL, Vermeeren A, Ramaekers JG (January 2006). "Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance". British Journal of Clinical Pharmacology. 61 (1): 79–86. doi:10.1111/j.1365-2125.2005.02524.x. PMC 1884990. PMID 16390354.
- ↑ Ortíz San Román L, Sanavia Morán E, Campos Domínguez M, Peinador García MM (December 2013). "[Anticholinergic syndrome due to dexchlorpheniramine as a cause of urinary retention]". Anales de Pediatria. 79 (6): 400–401. doi:10.1016/j.anpedi.2013.02.014. PMID 23680058.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 547. ISBN 9783527607495.
- ↑ Yamamura HI, Snyder SH (May 1974). "Muscarinic cholinergic binding in rat brain". Proceedings of the National Academy of Sciences of the United States of America. 71 (5): 1725–1729. Bibcode:1974PNAS...71.1725Y. doi:10.1073/pnas.71.5.1725. PMC 388311. PMID 4151898.
External links
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