Deltex E3 ubiquitin ligase 3

DTX3
Identifiers
Aliases	DTX3, RNF154, deltex3, deltex 3, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3
External IDs	OMIM: 613142; MGI: 2135752; HomoloGene: 12754; GeneCards: DTX3; OMA:DTX3 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,609,804 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,195,728 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; right frontal lobe; ; right uterine tube; ; endothelial cell; ; left ovary; ; body of uterus; ; right ovary; ; anterior cingulate cortex; ; nucleus accumbens;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; ventricular zone; ; habenula; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; transferase activity; zinc ion binding;
Cellular component	cytoplasm;
Biological process	Notch signaling pathway; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	196403
	80904
	ENSG00000178498
	ENSMUSG00000040415
	Q8N9I9
	Q80V91
	NM_001286245; NM_001286246; NM_178502
	NM_030714; NM_001368332
	NP_001273174; NP_001273175; NP_848597
	NP_109639; NP_001355261
	Wikidata
View/Edit Human	View/Edit Mouse

Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene.^[5] It is expressed in three isoform variants differing on the N-terminal end: DTX3a, DTX3b, and DTX3c.^[6] DTX3a and DTX3b have distinct sets of 7 or 10 N-terminal amino acids, while DTX3c has both consecutively with one amino acid substitution.^[6]

Function

DTX3 functions as an E3 ubiquitin ligase.^[7] Most but not all studies have found it to have a tumor-suppressing effect on human cancer: exceptions may be due to the failure to distinguish between different isoforms.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178498 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040415 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Deltex E3 ubiquitin ligase 3". Retrieved 2016-09-26.
1 2 3 Scalia, Pierluigi; Williams, Stephen J.; Suma, Antonio; Carnevale, Vincenzo (2023-06-21). "The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer". Cells. 12 (13): 1680. doi:10.3390/cells12131680. ISSN 2073-4409. PMC 10340142. PMID 37443713.
↑ Takeyama, Kunihiko; Aguiar, Ricardo C. T.; Gu, Liqun; He, Chunyan; Freeman, Gordon J.; Kutok, Jeffery L.; Aster, Jon C.; Shipp, Margaret A. (2003-06-13). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–21937. doi:10.1074/jbc.M301157200. ISSN 0021-9258. PMID 12670957.

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Deltex E3 ubiquitin ligase 3

Function

References

Further reading