Disco interacting protein 2 homolog C

DIP2C
Identifiers
Aliases	DIP2C, KIAA0934, disco interacting protein 2 homolog C
External IDs	OMIM: 611380; MGI: 1920179; GeneCards: DIP2C
Gene location (Human) Chr. Chromosome 10 (human) Band 10p15.3 Start 274,190 bp End 689,668 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A1 Start 9,326,564 bp End 9,718,964 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue middle frontal gyrus paraflocculus of cerebellum tibia middle temporal gyrus saphenous vein quadriceps femoris muscle vastus lateralis muscle endothelial cell Region I of hippocampus proper Top expressed in lateral septal nucleus facial motor nucleus pontine nuclei olfactory tubercle amygdala nucleus accumbens superior cervical ganglion substantia nigra medial vestibular nucleus anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function catalytic activity molecular function Cellular component cellular component Biological process metabolism biological process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 22982 208440 Ensembl ENSG00000151240 ENSMUSG00000048264 UniProt Q9Y2E4 n/a RefSeq (mRNA) NM_014974 NM_001081426 NM_172459 RefSeq (protein) NP_055789 n/a Location (UCSC) Chr 10: 0.27 – 0.69 Mb Chr 13: 9.33 – 9.72 Mb PubMed search
Wikidata
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Disco interacting protein 2 homolog C is a protein that in humans is encoded by the DIP2C gene.

Function

This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008].

Further reading

• Mukhopadhyay M, Pelka P, DeSousa D, Kablar B, Schindler A, Rudnicki MA, Campos AR (June 2002). "Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog". Gene. 293 (1–2): 59–65. doi:10.1016/s0378-1119(02)00694-7. PMID 12137943.
• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (April 2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Li WD, Jiao H, Wang K, Zhang CK, Glessner JT, Grant SF, Zhao H, Hakonarson H, Arlen Price R (September 2013). "A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls". Obesity (Silver Spring). 21 (9): E490–4. doi:10.1002/oby.20303. PMC 3762924. PMID 23703922.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.