Allocoprococcus comes
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| Allocoprococcus comes | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Lachnospiraceae |
| Genus: | Allocoprococcus |
| Species: | A. comes |
| Binomial name | |
| Allocoprococcus comes (Holdeman and Moore 1974) Yamamoto et al. 2026[1] | |
| Synonyms | |
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Allocoprococcus comes is an obligately anaerobic, Gram-positive, non-motile bacterium in the family Lachnospiraceae. It was originally isolated from human feces.[2] It is the type species of the genus Allocoprococcus.[1]
The species was originally described in 1974 as Coprococcus comes[2] Genome-based analyses later showed that it was phylogenetically distinct from the type species of Coprococcus. In 2026, it was transferred to the newly established genus Allocoprococcus as A. comes.[3] Coprococcus comes is therefore a homotypic synonym of the current name.[1] The specific epithet comes is Latin for "companion" or "fellow traveller", referring to the organism's occurrence in human feces.[1]
Description
[edit]Cells are elongated cocci with tapered ends, measuring about 1.6–2.3 μm in length and occurring in chains of approximately 4–20 cells. In culture, the organism forms translucent, lenticular or bifoliate colonies.[2]
Members of this species ferment carbohydrates, including glucose, arabinose and xylose.[2]
Drug metabolism
[edit]A 2022 study found that the bacterium hydrolyzed the ester ACE inhibitors quinapril and ramipril. In spontaneously hypertensive rats, administration of the bacterium reduced the blood-pressure-lowering effect of quinapril; the non-ester ACE inhibitor lisinopril was not affected.[4]
References
[edit]- 1 2 3 4 Allocoprococcus comes in LPSN; Freese, H. M.; Meier-Kolthoff, J. P.; Sardà Carbasse, J.; Afolayan, A. O.; Göker, M. (29 October 2025). "TYGS and LPSN in 2025: a Global Core Biodata Resource for genome-based classification and nomenclature of prokaryotes within DSMZ Digital Diversity". Nucleic Acids Research. 53: D1–D12. doi:10.1093/nar/gkaf1110.
- 1 2 3 4 Holdeman, L. V.; Moore, W. E. C. (1974). "New genus, Coprococcus, twelve new species, and emended descriptions of four previously described species of bacteria from human feces". International Journal of Systematic Bacteriology. 24 (2): 260–277. doi:10.1099/00207713-24-2-260.
- ↑ Yamamoto, Eri; Hisatomi, Atsushi; Miwa, Kana; Sakurai, Naomi; Koizumi, Akiko; Ohkuma, Moriya; Tsuchihashi, Hanae; Sakamoto, Mitsuo (2026). "Proposal of two novel species, Allocoprococcus similis gen. nov., sp. nov. and Faecalimonas hominis sp. nov., isolated from human faeces and genome-based reorganization of the genus Coprococcus". International Journal of Systematic and Evolutionary Microbiology. 76 (1) 007011. doi:10.1099/ijsem.0.007011. PMC 12778736. PMID 41498776.
- ↑ Yang, Tao; Mei, Xue; Tackie-Yarboi, Ethel; Akere, Millicent Tambari; Kyoung, Jun; Mell, Blair; Yeo, Ji-Youn; Cheng, Xi; Zubcevic, Jasenka; Richards, Elaine M.; Pepine, Carl J.; Raizada, Mohan K.; Schiefer, Isaac T.; Joe, Bina (2022). "Identification of a gut commensal that compromises the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors". Hypertension. 79 (8): 1591–1601. doi:10.1161/HYPERTENSIONAHA.121.18711. PMC 9278702. PMID 35538603.