-epi-isozizaene.svg)
+ 4 reduced
ferredoxin
Epi-isozizaene 5-monooxygenase
(Redirected from CYP170A1)
| Epi-isozizaene 5-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.15.39 | ||||||||
| CAS no. | 1207718-51-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Epi-isozizaene 5-monooxygenase (EC 1.14.15.39, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating).[1] This enzyme catalyses the following overall chemical reaction:
The enzyme from Streptomyces coelicolor is an oxidoreductase which uses molecular oxygen to insert a hydroxy group into (+)-epi-isozizaene and then further oxidises that intermediate to the ketone product. It requires ferredoxin to transfer electrons to the cytochrome P450 active site.[2]
References
[edit]- ↑ Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE (March 2008). "Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)". The Journal of Biological Chemistry. 283 (13): 8183–9. doi:10.1074/jbc.M710421200. PMC 2276382. PMID 18234666.
- ↑ Enzyme 1.14.15.39 at KEGG Pathway Database.
External links
[edit]- Epi-isozizaene+5-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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