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U-92016-A

From Wikipedia, the free encyclopedia
(Redirected from C19H25N3)
U-92016-A
Clinical data
Other namesU-92016A; U-92016-A; U92016A; U92016-A; U-92,016-A
Drug classSerotonin 5-HT1A receptor agonist
Identifiers
  • (8R)-8-(Dipropylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-2-carbonitrile
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H25N3
Molar mass295.430 g·mol−1
3D model (JSmol)
  • N#Cc3cc1c(ccc2c1C[C@H](N(CCC)CCC)CC2)[nH]3
  • InChI=1S/C19H25N3/c1-3-9-22(10-4-2)16-7-5-14-6-8-19-18(17(14)12-16)11-15(13-20)21-19/h6,8,11,16,21H,3-5,7,9-10,12H2,1-2H3/t16-/m1/s1 checkY
  • Key:WDDZPZKGLZNGEH-MRXNPFEDSA-N checkY
  (verify)

U-92016A, or U92016A, is a potent, high efficacy, and selective serotonin 5-HT1A receptor full agonist with a long duration of action.[1][2] It has been suggested that it could be developed as an anxiolytic or antidepressant.[1]

See also

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References

[edit]
  1. 1 2 Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F (1993). "Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants". J Med Chem. 36 (15): 2066–2074. doi:10.1021/jm00067a003. PMID 8101876.
  2. ↑ McCall RB, Romero AG, Bienkowski MJ, Harris DW, McGuire JC, Piercey MF, Shuck ME, Smith MW, Svensson KA, Schreur PJ, et al. (1994). "Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist". J Pharmacol Exp Ther. 271 (2): 875–883. doi:10.1016/S0022-3565(25)23851-4. PMID 7965808.
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