Amixetrine
(Redirected from C17H27NO)
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| Routes of administration | Oral |
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| Formula | C17H27NO |
| Molar mass | 261.409 g·mol−1 |
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Amixetrine (INN; brand name Somagest; developmental code CERM-898) is a drug that was formerly marketed in France but is now no longer sold.[1][2] According to various sources it has been said to be an anti-inflammatory, antidepressant, antispasmodic, anticholinergic, antihistamine, and antiserotonergic, but its definitive indications and pharmacology are unclear.[1][2] The drug was first synthesized in 1969 and was introduced in France in 1972.[1][2]
Synthesis
[edit]The treatment of isoamyl alcohol (1) with styrene (2) at −10 °C with dropwise addition of tert-butyl hypobromite gives (2-bromo-1-(isopentyloxy)ethyl)benzene (3).[3][4] Displacement of the halogen leaving group by pyrrolidine completes the synthesis of amixetrine (4).
References
[edit]- 1 2 3 Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 80–. ISBN 978-1-4757-2085-3.
- 1 2 3 William Andrew Publishing (22 October 2013). "Amixetrine Hydrochloride". Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Elsevier. pp. 285–. ISBN 978-0-8155-1856-3.
- ↑ GB 1253818 idem Mauvernay Roland Yves, Norbert Busch, DE1811767A1 (1969 to Ct Europ De Rech S Mauvernay)
- ↑ "-Butyl Hypobromite". Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons. 2009. doi:10.1002/047084289X.rb387.pub2. ISBN 978-0-470-84289-8.