IHCH-7113

IHCH-7113
Clinical data
Other names	IHCH7113
Drug class	Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
Identifiers
	IUPAC name (10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-triene;
CAS Number	313368-85-3 ;
PubChem CID	21302499;
ChemSpider	113607216;
UNII	C5DN9QL3UY;
Chemical and physical data
Formula	C14H19N3
Molar mass	229.327 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCN2[C@H]3CCNC[C@H]3C4=C2C1=CC=C4;
	InChI InChI=1S/C14H19N3/c1-16-7-8-17-12-5-6-15-9-11(12)10-3-2-4-13(16)14(10)17/h2-4,11-12,15H,5-9H2,1H3/t11-,12-/m0/s1; Key:QLGUCSLWLPCOTR-RYUDHWBXSA-N;

IHCH-7113 is a serotonin 5-HT_2A receptor agonist and serotonergic psychedelic of the pyridopyrroloquinoxaline family. It was derived by structural simplification of the serotonin 5-HT_2A receptor antagonist and atypical antipsychotic lumateperone. Other related compounds include IHCH-7079 and IHCH-7086, which were found to be non-hallucinogenic biased serotonin 5-HT_2A receptor agonists that were active in antidepressant assays but did not produce psychedelic-like responding in mice. IHCH-7113 on the other hand produced a head-twitch response comparable to that of DOI or LSD, which was blocked by the serotonin 5-HT_2A receptor antagonist volinanserin.^[1]^[2]^[3] The drug is not a controlled substance in the United States^[4] or Canada.^[5]

References

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