ATPase ASNA1

GET3
Identifiers
Aliases	GET3, ARSA-I, ARSA1, ASNA-I, TRC40, hASNA-I, arsA arsenite transporter, ATP-binding, homolog 1 (bacterial), ASNA1, Guided Entry Of Tail-Anchored Proteins Factor 3, ATPase
External IDs	OMIM: 601913; MGI: 1928379; HomoloGene: 31513; GeneCards: GET3; OMA:GET3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,748,323 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,751,910 bp
RNA expression pattern
	Top expressed in
	monocyte; ; stromal cell of endometrium; ; prefrontal cortex; ; right adrenal gland; ; apex of heart; ; right adrenal cortex; ; right frontal lobe; ; left adrenal gland; ; right testis; ; islet of Langerhans;
	Top expressed in
	choroid plexus of fourth ventricle; ; yolk sac; ; epiblast; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; superior frontal gyrus; ; primary visual cortex; ; central gray substance of midbrain; ; perirhinal cortex; ; medulla oblongata;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; protein binding; hydrolase activity; ATP binding; arsenite transmembrane transporter activity; metal ion binding; transporter activity; ATPase-coupled transmembrane transporter activity;
Cellular component	cytoplasm; nucleolus; extracellular exosome; endoplasmic reticulum membrane; nucleus; endoplasmic reticulum; GET complex;
Biological process	IRE1-mediated unfolded protein response; inorganic anion transport; transport; posttranslational protein targeting to endoplasmic reticulum membrane; arsenite transport; protein insertion into ER membrane; tail-anchored membrane protein insertion into ER membrane;
	Sources:Amigo / QuickGO
Orthologs
	439
	56495
	ENSG00000198356
	ENSMUSG00000052456
	O43681
	O54984
	NM_004317
	NM_019652; NM_001357202; NM_001357203
	NP_004308; NP_001358417; NP_001358418
	NP_062626; NP_001344131; NP_001344132
	Wikidata
View/Edit Human	View/Edit Mouse

ATPase GET3 (also known as ATPase ASNA1, arsenical pump-driving ATPase and arsenite-stimulated ATPase) is an enzyme that in humans is encoded by the gene GET3 (previously ASNA1).^[5]^[6]

Function

GET3 is the human homolog of the bacterial arsA gene. In E. coli, arsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.^[6]

Interactions

The protein GET3 is found to interact with FAM71D according to STRING^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198356 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052456 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kurdi-Haidar B, Aebi S, Heath D, Enns RE, Naredi P, Hom DK, Howell SB (Feb 1997). "Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter". Genomics. 36 (3): 486–91. doi:10.1006/geno.1996.0494. PMID 8884272.
1 2 "Entrez Gene: ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)".
↑ "STRING 10". Archived from the original on 2013-05-15. Retrieved 2015-05-11.

External links

Human ASNA1 genome location and ASNA1 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kurdi-Haidar B, Heath D, Aebi S, Howell SB (1998). "Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I)". J. Biol. Chem. 273 (35): 22173–6. doi:10.1074/jbc.273.35.22173. PMID 9712828.
Kurdi-Haidar B, Hom DK, Flittner DE, et al. (1998). "Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I)". J. Cell. Biochem. 71 (1): 1–10. doi:10.1002/(SICI)1097-4644(19981001)71:1<1::AID-JCB1>3.0.CO;2-#. PMID 9736449. S2CID 196597195.
Kurdi-Haidar B, Heath D, Lennon G, Howell SB (2000). "Chromosomal localization and genomic structure of the human arsenite-stimulated ATPase (hASNA-I)". Somat. Cell Mol. Genet. 24 (5): 307–11. doi:10.1023/B:SCAM.0000007134.16744.8b. PMID 10696239. S2CID 11936516.
Kao G, Nordenson C, Still M, et al. (2007). "ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells". Cell. 128 (3): 577–87. doi:10.1016/j.cell.2006.12.031. PMID 17289575. S2CID 2120123.
Stefanovic S, Hegde RS (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER". Cell. 128 (6): 1147–59. doi:10.1016/j.cell.2007.01.036. PMID 17382883. S2CID 16802797.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198356 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052456 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884272-5] Kurdi-Haidar B, Aebi S, Heath D, Enns RE, Naredi P, Hom DK, Howell SB (Feb 1997). "Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter". Genomics. 36 (3): 486–91. doi:10.1006/geno.1996.0494. PMID 8884272.

[entrez-6] 1 2 "Entrez Gene: ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)".

[7] "STRING 10". Archived from the original on 2013-05-15. Retrieved 2015-05-11.

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ATPase ASNA1

Function

Interactions

References

External links

Further reading