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Definition

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Polio, also called poliomyelitis, or infantile paralysis, is an infectious disease caused by the poliovirus.[1]

Definition of the Poliovirus

Symptoms

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Polio causes muscle weakness, resulting in an inability to move in roughly one half percent of people, who are infected with the virus.[1]

Symptoms of the Poliovirus

Onset of symptoms

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This can occur over a few hours, to a few days.[1][2]

Onset of Symptoms for Poliovirus

Areas of the body affected

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The weakness most often involves the legs, but can also include the muscles of the head, neck, and diaphragm.[1]

Areas of the Body Affected by the Poliovirus

Risk of death

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Many people fully recover,[1] but there is a risk of death. About 2 to 5 percent of children, and 15 to 30 percent of adults die, if they develop muscle weakness.[1]

Risk of Death in Humans by the Poliovirus

Minor symptoms

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Another 25 percent of people infected have minor symptoms such as fever, and a sore throat, that resolve in one to two weeks[1] . Five percent have headache, neck stiffness, and pains in the arms and legs.[1][2] About 70 percent of infections have no symptoms at all.[1]

Minor Symptoms of Poliovirus

Post-polio syndrome

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Years after recovery, post-polio syndrome may occur with a slow development of muscle weakness, similar to the person's original symptoms.[3]

Post Polio Syndrome

Spread

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Poliovirus is usually spread from person to person through infected fecal matter entering the mouth, [1] from food or water containing human feces, and less commonly from infected saliva.[1][2]

Spread of the Poliovirus

Duration of infectiousness

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Those who are infected may spread the disease for up to six weeks, even if no symptoms are present.[1]

Duration of Infectiousness of Poliovirus

Diagnosis

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The disease may be diagnosed by finding the virus in the feces, or detecting antibodies against it in the blood.[1] The disease only occurs naturally in humans.[1]

Diagnosis of Poliovirus

Prevention

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Polio is preventable with the polio vaccine; however, multiple doses are required for it to be effective.[2]

Prevention of Poliovirus

Vaccine boosters

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The US Centers for Disease Control and Prevention recommends polio vaccination boosters for travelers, and those who live in countries where the disease is occurring.[4]

Vaccine Boosters for Poliovirus

Treatment and current cases

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Once infected there is no specific treatment.[2] In 2024, there were 98 cases of wild polio, and over 190 cases of vaccine-derived polio.[5][6] This is down from 350,000 wild cases in 1988.[2] In 2024, the disease was only spread between people in Afghanistan and Pakistan.[5]

Treatment and Updated Current Cases of Poliovirus

History

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Poliomyelitis has existed for thousands of years, with depictions of the disease in ancient art.[1] The disease was first recognized as a distinct condition by the English physician Michael Underwood in 1789,[1] and the virus that causes it was first identified in 1908 by the Austrian immunologist Karl Landsteiner.[7]

History of the Poliovirus

History of endemic polio

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Major outbreaks started to occur in the late 19th century, in Europe and the United States.[1] In the 20th century it became one of the most worrying childhood diseases in these areas.[8]

History of Endemic Poliovirus

History of the polio vaccine

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The first effective polio vaccine was developed in the 1950s by Jonas Salk.[9] In 2013, the World Health Organization hoped that vaccination efforts, and early detection of cases would result in global eradication of the disease by 2018.[10] This has obviously not occurred, and there are concerns the disease is re-emerging.[11]

History of the Poliovirus Vaccine

References

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  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 Hamborsky J, Kroger A, Wolfe C, eds. (2015), "Poliomyelitis", Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book) (13th ed.), Washington DC: Public Health Foundation, (chap. 18), archived from the original on 30 December 2016.
  2. 1 2 3 4 5 6 "Poliomyelitis Fact sheet N°114". who.int. October 2014. Archived from the original on 18 April 2017. Retrieved 3 November 2014.
  3. "Post-Polio Syndrome Fact Sheet". NIH. 16 April 2014. Archived from the original on 29 July 2011. Retrieved 4 November 2014.
  4. "Guidance to US Clinicians Regarding New WHO Polio Vaccination Requirements for Travel by Residents of and Long-term Visitors to Countries with Active Polio Transmission". CDC. 2 June 2014. Archived from the original on 4 June 2014. Retrieved 4 June 2014.
  5. 1 2 "GPEI-Wild Poliovirus count". Retrieved 31 January 2025.
  6. "Statement of the fortieth meeting of the Polio IHR Emergency Committee". www.who.int. Archived from the original on 26 January 2025. Retrieved 31 January 2025. Archived 26 January 2025 at the Wayback Machine
  7. Daniel, Thomas M.; Robbins, Frederick C., eds. (1999). Polio (1st ed.). Rochester, N.Y.: University of Rochester Press. p. 11. ISBN 9781580460668. Archived from the original on 17 June 2016.
  8. Wheeler, Derek S.; Wong, Hector R.; Shanley, Thomas P., eds. (2009). Science and practice of pediatric critical care medicine. London: Springer. pp. 10–11. ISBN 9781848009219. Archived from the original on 17 June 2016.
  9. Aylward R (2006). "Eradicating polio: today's challenges and tomorrow's legacy". Annals of Tropical Medicine and Parasitology. 100 (5–6): 401–13. doi:10.1179/136485906X97354. PMID 16899145.
  10. "Global leaders support new six-year plan to deliver a polio-free world by 2018". who.int. 25 April 2013. Archived from the original on 18 October 2014. Retrieved 4 November 2014.
  11. "The history of Polio – from eradication to re-emergence - PAHO/WHO | Pan American Health Organization". www.paho.org. PAHO. Retrieved 25 June 2025.

MDWiki:Video:Polio