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UCD0829

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UCD0829
Clinical data
Other namesUCD-0829
Drug classSerotonin 5-HT2C receptor agonist
ATC code
  • None
Identifiers
  • N,N-dimethyl-4,5,6,7-tetrahydro-2H-isoindol-5-amine
PubChem CID
Chemical and physical data
FormulaC10H16N2
Molar mass164.252 g·mol−1
3D model (JSmol)
  • CN(C)C1CCC2=CNC=C2C1
  • InChI=1S/C10H16N2/c1-12(2)10-4-3-8-6-11-7-9(8)5-10/h6-7,10-11H,3-5H2,1-2H3
  • Key:RGEMPCYKTLPDNB-UHFFFAOYSA-N

UCD0829, also known as N,N-dimethyl-4,5,6,7-tetrahydro-2H-isoindol-5-amine, is a serotonin 5-HT2C receptor agonist and a partial ergoline.[1] It showed no affinity for nor agonism of the serotonin 5-HT2A and 5-HT2B receptors.[1] On the other hand, UCD0829 was a low-potency, moderate-efficacy partial agonist of the serotonin 5-HT2C receptor, with an EC50Tooltip half-maximal effective concentration of 1,660 nM and an EmaxTooltip maximal efficacy of 43%.[1] In accordance with its lack of serotonin 5-HT2A receptor agonism, UCD0829 failed to produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[1] The chemical synthesis of UCD0829 has been described.[1] UCD0829 was first described in the scientific literature by David E. Olson and colleagues by 2026.[1]

See also

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References

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  1. 1 2 3 4 5 6 Basargin AG, Domokosa A, Hennessey JJ, Aarrestad IK, Sambyal R, Khatib YA, Krüger J, Dunlap LE, Carter SJ, Rebek IA, McKee JL, Schalk SS, Liu M, Fettinger JC, Gonzalez MA, Potluri A, Tantillo DJ, Fiehn O, McCorvy JD, Olson DE (September 2026). "Deconstruction of lysergic acid diethylamide". Proceedings of the National Academy of Sciences of the United States of America. 123 (38) e2603412123. doi:10.1073/pnas.2603412123. PMID 42709856.


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