Template:Relative affinities of levonorgestrel and metabolites

Relative affinities (%) of levonorgestrel and metabolites

Compound	PRTooltip Progesterone receptor	ARTooltip Androgen receptor	ERTooltip Estrogen receptor	GRTooltip Glucocorticoid receptor	MRTooltip Mineralocorticoid receptor	SHBGTooltip Sex hormone-binding globulin	CBGTooltip Transcortin
Levonorgestrel	150–162	34a, 45	0	1–8	17–75	50	0
5α-Dihydrolevonorgestrel	50	38a	0	?	?	?	?
3α,5α-Tetrahydrolevonorgestrel	?	?	0.4	?	?	?	?
3β,5α-Tetrahydrolevonorgestrel	?	?	2.4	?	?	?	?
Notes: Values are percentages (%). Reference ligands (100%) were promegestone for the PRTooltip progesterone receptor, metribolone (a = mibolerone) for the ARTooltip androgen receptor, E2 for the ERTooltip estrogen receptor, DEXATooltip dexamethasone for the GRTooltip glucocorticoid receptor, aldosterone for the MRTooltip mineralocorticoid receptor, DHTTooltip dihydrotestosterone for SHBGTooltip sex hormone-binding globulin, and cortisol for CBGTooltip Transcortin. Sources:

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