Talk:PIDD1

Possible AI-generated content

Concerns have been raised about AI-generated content in this article. This is a procedural talk page section to discuss it. The rationale given is: this large 2024 expansion; note WP:AISIGNS in superficial analyses, undue emphasis on significance, vocab distro typical of 2024 LLM output etc Gnomingstuff (talk) 04:49, 10 May 2026 (UTC)

Well this is depressing. At the very least, it seems likely that LLMs did a significant part of the work, though maybe with some human editing afterwards (or vice versa). I don't know the subject well enough to fact check, but in many places references are just not relevant to the claims

Recently, four homozygous variants in the PIDD1 gene have been identified among 11 individuals from five separate families, all of whom present with nonsyndromic intellectual disability. Nevertheless, comprehensive clinical and neuroimaging data for these cases are limited.[10]

Which cites the original discovery paper, which is neither recent nor talks about human gene mutations.

Or

Importantly, caspase-2 and the PIDDosome play essential role in "polyploidy checkpoint." Triggered by the presence of extra centrosomes (supernumeray centrosomes), which often occur following unsuccessful cell division (cytokinesis), the PIDDosome activates caspase-2. This activation leads to the proteolytic inactivation of MDM2, resulting in the activation of a p53 response. Additionally, recent research has connected caspase-2 to the monitoring of aneuploidy in cancer, although the exact mechanisms involved are not yet clearly defined.[52][53][54]

There is a paper about supernumerary centrosomes, but the ones cited are not it.

There also seems to be just a general conflation of this gene and other genes like CADD1/CASP2, and lots of meandering text that don't seem to be too related to this specific protein. Like why does it spend more time talking about the disease caused by CRADD mutations rather than the disease caused by actual mutations in this gene?

The original post was also filled with bad formatting, and erroneously copied web navigation text. I'm not sure if that makes me more think it was written by AI or careless edits by a human, but it does not inspire confidence.

It might need to be all reverted because it's too hard to tell what's human vs. LLM, but I don't think I'm going to be the one to do it Pabnau (talk) 19:22, 9 September 2026 (UTC)

Moving page

The current page name, LRDD, is an outdated gene symbol. The uniprot protein name, "p53-induced death domain-containing protein 1", is too long, so I will try to move the page to the new gene symbol: "PIDD1". Pabnau (talk) 18:14, 9 September 2026 (UTC)